(Q34395718)

1 August 2017

Stable cellular senescence is associated with persistent DDR activation (English)

1 reference

Fabrizio d'Adda di Fagagna

1 August 2017

1 reference

series ordinal

4

object named as

Fabrizio d'Adda di Fagagna

1 reference

1 August 2017

Chiara Mondello

3

0 references

author name string

Marzia Fumagalli

series ordinal

1

1 reference

PubMed ID

25340529

1 August 2017

Francesca Rossiello

series ordinal

2

1 reference

PubMed ID

25340529

1 August 2017

language of work or name

English

0 references

publication date

23 October 2014

1 reference

1 August 2017

1 reference

1 August 2017

9

1 reference

1 August 2017

10

1 reference

1 August 2017

e110969

1 reference

Creative Commons Attribution 4.0 International

1 August 2017

start time

23 October 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

1 reference

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Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

6 July 2018

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Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence.

6 July 2018

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Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

6 July 2018

1 reference

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

6 July 2018

1 reference

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Accumulation of DNA damage in hematopoietic stem and progenitor cells during human aging

6 July 2018

1 reference

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Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer.

6 July 2018

1 reference

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The DNA-damage response in human biology and disease

6 July 2018

1 reference

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Telomere dynamics during replicative senescence are not directly modulated by conditions of oxidative stress in IMR90 fibroblast cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Cellular senescence: hot or what?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Living on a break: cellular senescence as a DNA-damage response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Cellular senescence: when bad things happen to good cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

DNA repair is limiting for haematopoietic stem cells during ageing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

p53 mediates senescence-like arrest induced by chronic replicational stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Accumulation of senescent cells in mitotic tissue of aging primates

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Identification of p38MAPK-dependent genes with changed transcript abundance in H2O2-induced premature senescence of IMR-90 hTERT human fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

p16INK4a induces an age-dependent decline in islet regenerative potential

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

BRAFE600-associated senescence-like cell cycle arrest of human naevi

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Human cell senescence as a DNA damage response.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Does a sentinel or a subset of short telomeres determine replicative senescence?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

A DNA damage checkpoint response in telomere-initiated senescence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Developmental differences in the immortalization of lung fibroblasts by telomerase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

DNA damage foci at dysfunctional telomeres

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Reversal of human cellular senescence: roles of the p53 and p16 pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Werner syndrome protein limits MYC-induced cellular senescence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Stress-induced premature senescence in BJ and hTERT-BJ1 human foreskin fibroblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Immortalisation and transformation revisited

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Extension of life-span by introduction of telomerase into normal human cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest

6 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110969

Cellular senescence in aging primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110969

Cytogenetic analysis of human cells reveals specific patterns of DNA damage in replicative and oncogene-induced senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110969

Disappearance of the telomere dysfunction-induced stress response in fully senescent cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110969

Karyotype instability and anchorage-independent growth in telomerase-immortalized fibroblasts from two centenarian individuals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110969

p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0110969

Prolonged culture of telomerase-immortalized human fibroblasts leads to a premalignant phenotype.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4207795

Deep senescent human fibroblasts show diminished DNA damage foci but retain checkpoint capacity to oxidative stress

9 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25340529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA damage response and cellular senescence in tissues of aging mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25340529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25340529

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0110969

1 reference

1 August 2017

0 references

1 reference

1 August 2017

1 reference

PubMed ID

25340529