(Q42406043)

English

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain.

scientific article published on 31 May 2016

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scholarly article

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3 April 2020

The α7 nicotinic receptor dual allosteric agonist and positive allosteric modulator GAT107 reverses nociception in mouse models of inflammatory and neuropathic pain (English)

1 reference

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3 April 2020

neuropathic pain

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sensory perception of pain

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based on heuristic

inferred from title

Jenny Wilkerson

2

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3 April 2020

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3 April 2020

author name string

Deniz Bagdas

1

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3 April 2020

Abhijit Kulkarni

3

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3 April 2020

Wisam Toma

4

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3 April 2020

Shakir AlSharari

5

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3 April 2020

Aron H Lichtman

7

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3 April 2020

Roger L Papke

8

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3 April 2020

Ganesh A Thakur

9

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3 April 2020

M Imad Damaj

10

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publication date

18 July 2016

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3 April 2020

British Journal of Pharmacology

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3 April 2020

173

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3 April 2020

16

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3 April 2020

2506-2520

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3 April 2020

Critical Molecular Determinants of α7 Nicotinic Acetylcholine Receptor Allosteric Activation: SEPARATION OF DIRECT ALLOSTERIC ACTIVATION AND POSITIVE ALLOSTERIC MODULATION.

1 reference

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28 May 2018

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

1 reference

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28 May 2018

The Concise Guide to PHARMACOLOGY 2015/16: Ligand-gated ion channels.

1 reference

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28 May 2018

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

1 reference

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28 May 2018

The Antinociceptive and Antiinflammatory Properties of 3-furan-2-yl-N-p-tolyl-acrylamide, a Positive Allosteric Modulator of α7 Nicotinic Acetylcholine Receptors in Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Acetylcholine Inhibits LPS-Induced MMP-9 Production and Cell Migration via the α7 nAChR-JAK2/STAT3 Pathway in RAW264.7 Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity

1 reference

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28 May 2018

Experimental design and analysis and their reporting: new guidance for publication in BJP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Looking below the surface of nicotinic acetylcholine receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP.

1 reference

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28 May 2018

The role of alpha5 nicotinic acetylcholine receptors in mouse models of chronic inflammatory and neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

The analgesic-like properties of the alpha7 nAChR silent agonist NS6740 is associated with non-conducting conformations of the receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Microwave-assisted Expeditious and Efficient Synthesis of Cyclopentene Ring-fused Tetrahydroquinoline Derivatives Using Three-component Povarov Reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of α7 nicoti

1 reference

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28 May 2018

Neuronal nicotinic receptors as analgesic targets: it's a winding road

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Effects of α7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Functional α7 nicotinic ACh receptors on astrocytes in rat hippocampal CA1 slices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

A series of α7 nicotinic acetylcholine receptor allosteric modulators with close chemical similarity but diverse pharmacological properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Targeting astrocyte signaling for chronic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

Animal research: reporting in vivo experiments: the ARRIVE guidelines

1 reference

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28 May 2018

Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology

1 reference

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28 May 2018

Proteomic analysis of an alpha7 nicotinic acetylcholine receptor interactome

1 reference

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28 May 2018

Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease

1 reference

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28 May 2018

Profiling of dynamically changed gene expression in dorsal root ganglia post peripheral nerve injury and a critical role of injury-induced glial fibrillary acidic protein in maintenance of pain behaviors [corrected].

1 reference

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28 May 2018

MAP kinase and pain

1 reference

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28 May 2018

Activation of spinal microglia in a murine model of peripheral inflammation-induced, long-lasting contralateral allodynia.

1 reference

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28 May 2018

p38 MAPK, microglial signaling, and neuropathic pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4959951

28 May 2018

The activation of nicotinic acetylcholine receptors enhances the inhibitory synaptic transmission in the deep dorsal horn neurons of the adult rat spinal cord

1 reference

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28 May 2018

Allosteric modulation of nicotinic acetylcholine receptors

1 reference

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28 May 2018

An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo

1 reference

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28 May 2018

Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats

1 reference

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28 May 2018

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

1 reference

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28 May 2018

Antinociceptive effects of choline against acute and inflammatory pain

1 reference

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28 May 2018

Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures

1 reference

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28 May 2018

Pharmacological stimulation of the cholinergic antiinflammatory pathway

1 reference

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28 May 2018

Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000).

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28 May 2018

Heteromeric complexes of alpha 5 and/or alpha 7 subunits. Effects of calcium and potential role in nicotine-induced presynaptic facilitation

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28 May 2018

Quantitative assessment of tactile allodynia in the rat paw

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28 May 2018

The formalin test: scoring properties of the first and second phases of the pain response in rats.

1 reference

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28 May 2018

The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests.

1 reference

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28 May 2018

The microglial α7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2.

1 reference

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16 August 2018

Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6.

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16 August 2018

Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

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16 August 2018

Activation of the cholinergic anti-inflammatory system by nicotine attenuates neuroinflammation via suppression of Th1 and Th17 responses

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16 August 2018

The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

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16 August 2018

The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system.

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16 August 2018

Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors

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16 August 2018

The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model

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16 August 2018

Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors.

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16 August 2018

Intrathecal morphine in mice: a new technique

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/BPH.13528

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27243753%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

1 reference

Europe PubMed Central

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3 April 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27243753%20AND%20SRC:MED&resulttype=core&format=json

3 April 2020

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