(Q42428773)

English

Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer

scientific article published on May 1996

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

Involvement of cytochrome P450, glutathione S-transferase, and epoxide hydrolase in the metabolism of aflatoxin B1 and relevance to risk of human liver cancer (English)

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

F. Peter Guengerich

1

object named as

F P Guengerich

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

author name string

W W Johnson

2

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

Y F Ueng

3

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

H Yamazaki

4

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

T Shimada

5

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

publication date

1 May 1996

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

Environmental Health Perspectives

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

104 Suppl 3

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

557-562

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Oxidation of aflatoxin B1 by bacterial recombinant human cytochrome P450 enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Inhibition of CYP1A2 and CYP3A4 by oltipraz results in reduction of aflatoxin B1 metabolism in human hepatocytes in primary culture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

The genetics of aflatoxin B1 metabolism. Association of the induction of aflatoxin B1-4-hydroxylase with the transcriptional activation of cytochrome P3-450 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Cytochrome P3-450 cDNA encodes aflatoxin B1-4-hydroxylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Inhibition by pentachlorophenol of the initiating and promoting activities of 1'-hydroxysafrole for the formation of enzyme-altered foci and tumors in rat liver.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

The Ah locus: genetic differences in toxicity, cancer, mutation, and birth defects

1 reference

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28 May 2018

Comparison of rates of enzymatic oxidation of aflatoxin B1, aflatoxin G1, and sterigmatocystin and activities of the epoxides in forming guanyl-N7 adducts and inducing different genetic responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Five of 12 forms of vaccinia virus-expressed human hepatic cytochrome P450 metabolically activate aflatoxin B1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Alteration of the aflatoxin cyclopentenone ring to a delta-lactone reduces intercalation with DNA and decreases formation of guanine N7 adducts by aflatoxin epoxides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Human cytochrome P450IIA3: cDNA sequence, role of the enzyme in the metabolic activation of promutagens, comparison to nitrosamine activation by human cytochrome P450IIE1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Purification and characterization of human liver microsomal cytochrome P-450 2A6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Glutathione S-transferase μ in human lymphocyte and liver: role in modulating formation of carcinogen-derived DNA adducts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Metabolic activation of carcinogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

The endo-8,9-epoxide of aflatoxin B1: a new metabolite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Aflatoxins as risk factors for hepatocellular carcinoma in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

28 May 2018

Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1469621

16 August 2018

Expression of modified human cytochrome P450 1A2 in Escherichia coli: stabilization, purification, spectral characterization, and catalytic activities of the enzyme.

1 reference

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16 August 2018

Analysis of numerical methods for computer simulation of kinetic processes: development of KINSIM--a flexible, portable system.

1 reference

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16 August 2018

Rat and human liver microsomal epoxide hydratase. Purification and evidence for the existence of multiple forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simultaneous purification of multiple forms of rat liver microsomal cytochrome P-450 by high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient intervention with oltipraz protects against aflatoxin-induced hepatic tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of human liver cytochrome P-450 debrisoquine 4-hydroxylase probed using immunochemical inhibition and chemical modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2,3-Dihydro-2-(guan-7-yl)-3-hydroxy-aflatoxin B1, a major acid hydrolysis product of aflatoxin B1-DNA or -ribosomal RNA adducts formed in hepatic microsome-mediated reactions and in rat liver in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation and characterization of the major serum albumin adduct formed by aflatoxin B1 in vivo in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Debrisoquine oxidation phenotype and susceptibility to lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and deactivation of aflatoxin B1 in isolated rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8781383

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1289/EHP.96104S3557

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

31 October 2017

ResearchGate publication ID

0 references

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