(Q42436880)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23568147%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Mitochondrial energetic and AKT status mediate metabolic effects and apoptosis of metformin in human leukemic cells (English)

1 reference

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28 February 2020

1 reference

1 reference

8

1 reference

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28 February 2020

Yvan Martineau

12

1 reference

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28 February 2020

Christophe Rocher

15

1 reference

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28 February 2020

Jean-Charles Portais

19

1 reference

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28 February 2020

author name string

S Scotland

1

1 reference

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28 February 2020

E Saland

2

1 reference

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28 February 2020

N Skuli

3

1 reference

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28 February 2020

F de Toni

4

1 reference

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28 February 2020

H Boutzen

5

1 reference

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28 February 2020

E Micklow

6

1 reference

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28 February 2020

I Sénégas

7

1 reference

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28 February 2020

L Peyriga

9

1 reference

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28 February 2020

F Théodoro

10

1 reference

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28 February 2020

E Dumon

11

1 reference

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28 February 2020

G Danet-Desnoyers

13

1 reference

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28 February 2020

F Bono

14

1 reference

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28 February 2020

T Levade

16

1 reference

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28 February 2020

S Manenti

17

1 reference

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28 February 2020

C Junot

18

1 reference

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28 February 2020

N Alet

20

1 reference

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28 February 2020

C Récher

21

1 reference

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28 February 2020

M A Selak

22

1 reference

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28 February 2020

M Carroll

23

1 reference

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28 February 2020

J-E Sarry

24

1 reference

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28 February 2020

publication date

9 April 2013

1 reference

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28 February 2020

1 reference

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28 February 2020

volume

27

1 reference

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28 February 2020

issue

11

1 reference

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28 February 2020

page(s)

2129-2138

1 reference

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https://scigraph.springernature.com/pub.10.1038/leu.2013.107

28 February 2020

exact match

0 references

cites work

Tumor cell metabolism: cancer's Achilles' heel

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Targeting cancer metabolism: a therapeutic window opens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

The warburg effect in leukemia-stroma cocultures is mediated by mitochondrial uncoupling associated with uncoupling protein 2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

AMP-dependent kinase/mammalian target of rapamycin complex 1 signaling in T-cell acute lymphoblastic leukemia: therapeutic implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Global reconstruction of the human metabolic network based on genomic and bibliomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Cell biology. Warburg effect and redox balance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Carbon source and myc expression influence the antiproliferative actions of metformin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Targeting survival cascades induced by activation of Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for effective leukemia therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K/PTEN/Akt/mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Dysregulated lipid metabolism in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

inferred from DOI database lookup

7 January 2021

based on heuristic

Reductive carboxylation supports growth in tumour cells with defective mitochondria.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2013.107

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2013.107

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23568147%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 February 2020

1013907394

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23568147%20AND%20SRC:MED&resulttype=core&format=json