(Q42459123)

English

Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant-negative mechanism

scientific article published on April 2004

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

1 November 2017

Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant-negative mechanism (English)

1 reference

Europe PubMed Central

1 November 2017

0 references

object named as

Gary R Hime

1

0 references

object named as

Carol Wicking

6

0 references

author name string

Hania Lada

2

1 reference

Europe PubMed Central

1 November 2017

Michael J Fietz

3

1 reference

Europe PubMed Central

1 November 2017

Susan Gillies

4

1 reference

Europe PubMed Central

1 November 2017

Abraham Passmore

5

1 reference

Europe PubMed Central

1 November 2017

Brandon J Wainwright

7

1 reference

Europe PubMed Central

1 November 2017

publication date

1 April 2004

1 reference

Europe PubMed Central

1 November 2017

Developmental Dynamics

1 reference

Europe PubMed Central

1 November 2017

229

1 reference

Europe PubMed Central

1 November 2017

4

1 reference

Europe PubMed Central

1 November 2017

780-790

1 reference

Europe PubMed Central

1 November 2017

The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Ci: a complex transducer of the hedgehog signal

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual roles for patched in sequestering and transducing Hedgehog

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Complications of the naevoid basal cell carcinoma syndrome: results of a population based study

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Developmental genes and cancer: role of patched in basal cell carcinoma of the skin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Nevoid basal cell carcinoma syndrome

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The Drosophila patched gene encodes a putative membrane protein required for segmental patterning

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Sonic hedgehog induces the segregation of patched and smoothened in endosomes

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Transducing Hedgehog: the story so far

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Hedgehog signaling in animal development: paradigms and principles

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the Drosophila patched gene in positional signalling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The sterol-sensing domain: multiple families, a unique role?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical evidence that patched is the Hedgehog receptor

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Biology of basal cell carcinoma (Part I).

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Dual pathways for induction of wingless expression by protein kinase A and Hedgehog in Drosophila embryos

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Wing formation in Drosophila melanogaster requires decapentaplegic gene function along the anterior-posterior compartment boundary

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonmelanoma cancers of the skin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

patched overexpression causes loss of wingless expression in Drosophila embryos.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Nevoid basal cell carcinoma syndrome: review of 118 affected individuals

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Transposition of cloned P elements into Drosophila germ line chromosomes.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The nevoid basal cell carcinoma syndrome

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Patched acts catalytically to suppress the activity of Smoothened

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

smoothened encodes a receptor-like serpentine protein required for hedgehog signalling

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.10499

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/DVDY.10499

1 reference

Europe PubMed Central

1 November 2017

1 reference

Europe PubMed Central

1 November 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q42459123&oldid=1958152200"