(Q42465835)

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Intracellular accumulation of amyloid-β (Aβ) protein plays a major role in Aβ-induced alterations of glutamatergic synaptic transmission and plasticity.

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16 February 2020

Intracellular accumulation of amyloid-β (Aβ) protein plays a major role in Aβ-induced alterations of glutamatergic synaptic transmission and plasticity (English)

1 reference

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16 February 2020

Roberto Piacentini

4

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16 February 2020

Cristian Ripoli

1

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16 February 2020

2

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16 February 2020

Domenica D Li Puma

3

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16 February 2020

7

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16 February 2020

Marcello D'Ascenzo

8

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16 February 2020

9

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16 February 2020

author name string

Alessia Mastrodonato

5

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16 February 2020

Federico Scala

6

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16 February 2020

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1 September 2014

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16 February 2020

Journal of Neuroscience

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16 February 2020

34

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16 February 2020

38

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16 February 2020

12893-12903

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16 February 2020

Intraneuronal Abeta42 accumulation in human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular accumulation of beta-amyloid(1-42) in neurons is facilitated by the alpha 7 nicotinic acetylcholine receptor in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake and pathogenic effects of amyloid beta peptide 1-42 are enhanced by integrin antagonists and blocked by NMDA receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease is a synaptic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid regulation of presynaptic nicotinic receptors in rat hippocampus and neocortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of dystrophin leads to the selective loss of superior cervical ganglion neurons projecting to muscular targets in genetically dystrophic mdx mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NMDA receptor trafficking by amyloid-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotagmin IV does not alter excitatory fast synaptic transmission or fusion pore kinetics in mammalian CNS neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's amyloid beta-peptide (1-42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: an intriguing role for methionine 35.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein overexpression depresses excitatory transmission through both presynaptic and postsynaptic mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The beta-amyloid protein of Alzheimer's disease binds to membrane lipids but does not bind to the alpha7 nicotinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular amyloid-beta in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional role of cyclic nucleotide-gated channels in rat medial vestibular nucleus neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysregulation of intracellular calcium homeostasis is responsible for neuronal death in an experimental model of selective hippocampal degeneration induced by trimethyltin

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of methionine 35 in the intracellular Ca2+ homeostasis dysregulation and Ca2+-dependent apoptosis induced by amyloid beta-peptide in human neuroblastoma IMR32 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abeta-dependent Inhibition of LTP in different intracortical circuits of the visual cortex: the role of RAGE

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic transmission block by presynaptic injection of oligomeric amyloid beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta from axons and dendrites reduces local spine number and plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Abeta42 and Alzheimer's disease neuropathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel therapeutics for Alzheimer's disease: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β as a modulator of synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surprising toxicity and assembly behaviour of amyloid β-protein oxidized to sulfone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing induced by herpes simplex virus type 1 (HSV-1) yields several APP fragments in human and rat neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: Recollection of lost memories

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraneuronally injected amyloid β inhibits long-term potentiation in rat hippocampal slices.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of olfactory-type cyclic nucleotide-gated channels in rat cortical astrocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role of intraneuronal Aβ in Alzheimer's disease: technical challenges in studying intracellular Aβ.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of different amyloid β-protein analogues on synaptic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Extremely low-frequency electromagnetic fields enhance the survival of newborn neurons in the mouse hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineering a memory with LTD and LTP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A synaptic model of memory: long-term potentiation in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

'Green mice' as a source of ubiquitous green cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25232124

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1201-14.2014

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232124%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232124%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232124%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

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