(Q42472843)

1 November 2017

title

The R6/2 transgenic mouse model of Huntington's disease develops diabetes due to deficient beta-cell mass and exocytosis (English)

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1 November 2017

0 references

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Karl Bacos

7

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Malin Fex

Malin Fex

2

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Jia-Yi Li

Jia-Yi Li

9

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Hindrik Mulder

Hindrik Mulder

12

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Sam Brundin

11

Patrik Brundin

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ORCID Public Data File 2021

1 November 2017

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author name string

Maria Björkqvist

1

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1 November 2017

Erik Renström

3

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1 November 2017

Nils Wierup

4

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1 November 2017

Asa Petersén

5

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1 November 2017

Joana Gil

6

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1 November 2017

Natalija Popovic

8

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1 November 2017

Frank Sundler

10

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1 November 2017

publication date

13 January 2005

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1 November 2017

published in

Human Molecular Genetics

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1 November 2017

volume

14

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1 November 2017

issue

5

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1 November 2017

page(s)

565-574

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Increased frequency of diabetes mellitus in patients with Huntington's chorea

1 November 2017

cites work

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https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Identification and localization of huntingtin in brain and human lymphoblastoid cell lines with anti-fusion protein antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Wild type Huntingtin reduces the cellular toxicity of mutant Huntingtin in mammalian cell models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Glutamine repeats and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Formation of polyglutamine inclusions in non-CNS tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Aging, energy, and oxidative stress in neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Expression of the Huntington's disease (IT15) protein product in HD patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Instability of highly expanded CAG repeats in mice transgenic for the Huntington's disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Nonapoptotic neurodegeneration in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Early alterations in gene expression and cell morphology in a mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Progressive retinal degeneration and dysfunction in R6 Huntington's disease mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Evaluation of R6/2 HD transgenic mice for therapeutic studies in Huntington's disease: behavioral testing and impact of diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Endocrine functions in Huntington's disease. A two-and-a-half years follow-up study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Insulin and neurodegenerative disease: shared and specific mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Neurodegenerative disorders associated with diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

The midgestational human fetal pancreas contains cells coexpressing islet hormones

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Islet somatostatin--microvascular, paracrine, and pulsatile regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Decreased hippocampal cell proliferation in R6/1 Huntington's mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Centrosome disorganization in fibroblast cultures derived from R6/2 Huntington's disease (HD) transgenic mice and HD patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Beta-cell adaptation and decompensation during the progression of diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDI053

21 January 2018

Identifiers

DOI

10.1093/HMG/DDI053

1 reference

1 November 2017

1 reference