(Q42500046)

1 November 2017

Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels (English)

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1 November 2017

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L Norton

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Ralph A. DeFronzo

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4

object named as

R A DeFronzo

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1 November 2017

B Doiron

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PubMed ID

22222503

1 November 2017

W Hu

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2

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1 November 2017

7 January 2012

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1 November 2017

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1 November 2017

55

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1 November 2017

3

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1 November 2017

719-728

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https://scigraph.springernature.com/pub.10.1007/s00125-011-2414-z

1 November 2017

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Metabolic and molecular basis of insulin resistance

21 January 2018

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Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals.

21 January 2018

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Current strategies for the inhibition of hepatic glucose production in type 2 diabetes

21 January 2018

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The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

21 January 2018

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Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study

21 January 2018

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beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis

21 January 2018

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Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study

21 January 2018

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The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes

21 January 2018

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Relationship between glucose tolerance, insulin secretion, and insulin action in non-obese individuals with varying degrees of glucose tolerance

21 January 2018

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Studies of pancreatic alpha cell function in normal and diabetic subjects

21 January 2018

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The replication of beta cells in normal physiology, in disease and for therapy

21 January 2018

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Preservation of beta-cell function by targeting beta-cell mass

21 January 2018

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Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

21 January 2018

1 reference

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Grb10 and Grb14: enigmatic regulators of insulin action--and more?

21 January 2018

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Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

21 January 2018

1 reference

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Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

21 January 2018

1 reference

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Grb10 exceeding the boundaries of a common signaling adapter.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Phosphorylation of grb10 regulates its interaction with 14-3-3

21 January 2018

1 reference

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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

21 January 2018

1 reference

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Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

21 January 2018

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Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Grb10 and active Raf-1 kinase promote Bad-dependent cell survival

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

21 January 2018

1 reference

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Lentiviral vectors--the promise of gene therapy within reach?

21 January 2018

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Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

21 January 2018

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Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?

21 January 2018

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Major DNA fragmentation is a late event in apoptosis

21 January 2018

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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

21 January 2018

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Grb10 interacts with Bim L and inhibits apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

21 January 2018

The BCL-2 family reunion

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Adaptation of the exocrine pancreas to diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Impaired glucose-induced glucagon suppression after partial pancreatectomy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Reduced insulin secretion by subtotal pancreatectomy: preservation of insulin sensitivity and glucose tolerance in postoperative patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Hyperglucagonemia and insulin-mediated glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2414-Z

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

21 January 2018

1 reference

12 December 2020

The biochemistry of cell death by apoptosis

1 reference

12 December 2020

Capacity to secrete islet hormones after subtotal pancreatectomy for pancreatic cancer.

1 reference

12 December 2020

Glucoregulation during insulin and glucagon deficiency: role of catecholamines

1 reference

12 December 2020

Evidence against GRB10 as the gene responsible for Silver-Russell syndrome

1 reference

12 December 2020

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1 reference

12 December 2020

Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics

1 reference

12 December 2020

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

1 reference

12 December 2020

10.1007/S00125-011-2414-Z

Identifiers

DOI

1 reference

1 November 2017

1 reference

PubMed ID

22222503