(Q42500046)

1 November 2017

title

Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels (English)

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1 November 2017

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L Norton

3

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Ralph A. DeFronzo

series ordinal

4

object named as

R A DeFronzo

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1 November 2017

B Doiron

1

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1 November 2017

W Hu

series ordinal

2

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1 November 2017

publication date

7 January 2012

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1 November 2017

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1 November 2017

volume

55

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1 November 2017

issue

3

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1 November 2017

page(s)

719-728

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https://scigraph.springernature.com/pub.10.1007/s00125-011-2414-z

1 November 2017

exact match

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cites work

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Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

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Grb10 and Grb14: enigmatic regulators of insulin action--and more?

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Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14

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Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains

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Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool

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Grb10 exceeding the boundaries of a common signaling adapter.

21 January 2018

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Phosphorylation of grb10 regulates its interaction with 14-3-3

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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

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Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes

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Inhibition of Raf-1 alters multiple downstream pathways to induce pancreatic beta-cell apoptosis.

21 January 2018

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Grb10 and active Raf-1 kinase promote Bad-dependent cell survival

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Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo

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Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors

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Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

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Grb10 interacts with Bim L and inhibits apoptosis

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21 January 2018

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Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopy

21 January 2018

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Impaired glucose-induced glucagon suppression after partial pancreatectomy.

21 January 2018

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Reduced insulin secretion by subtotal pancreatectomy: preservation of insulin sensitivity and glucose tolerance in postoperative patients.

21 January 2018

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Hyperglucagonemia and insulin-mediated glucose metabolism

21 January 2018

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Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis

21 January 2018

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Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea

21 January 2018

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A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

21 January 2018

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12 December 2020

The biochemistry of cell death by apoptosis

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12 December 2020

Capacity to secrete islet hormones after subtotal pancreatectomy for pancreatic cancer.

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12 December 2020

Glucoregulation during insulin and glucagon deficiency: role of catecholamines

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12 December 2020

Evidence against GRB10 as the gene responsible for Silver-Russell syndrome

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12 December 2020

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1 reference

12 December 2020

Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics

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12 December 2020

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

1 reference

12 December 2020

10.1007/S00125-011-2414-Z

Identifiers

DOI

1 reference

1 November 2017

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