Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q42546083)
Watch
English
Mdmx promotes genomic instability independent of p53 and Mdm2.
scientific article published on 10 March 2014
In more languages
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
title
Mdmx promotes genomic instability independent of p53 and Mdm2
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
author
Alexia Carrillo
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
author name string
A Bouska
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
M P Arrate
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
C M Eischen
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
language of work or name
English
0 references
publication date
10 March 2014
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
published in
Oncogene
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
volume
34
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
issue
7
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
page(s)
846-856
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
exact match
https://scigraph.springernature.com/pub.10.1038/onc.2014.27
0 references
cites work
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MDM2, MDMX and p53 in oncogenesis and cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Protecting the genome from mdm2 and mdmx
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MDM4 is a key therapeutic target in cutaneous melanoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Regulation of p53: a collaboration between Mdm2 and Mdmx
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Abnormal MDMX degradation in tumor cells due to ARF deficiency
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Hallmarks of Cancer: The Next Generation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
The MRE11 complex: starting from the ends.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Assembly and function of DNA double-strand break repair foci in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Transient ATM kinase inhibition disrupts DNA damage-induced sister chromatid exchange
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Genomic instability--an evolving hallmark of cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
The p53 orchestra: Mdm2 and Mdmx set the tone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Role of Mdm4 in drug sensitivity of breast cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MdmX regulates transformation and chromosomal stability in p53-deficient cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Mdm2 promotes genetic instability and transformation independent of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MDMX: from bench to bedside
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Inactivation of the p53 pathway in retinoblastoma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Requirement of the MRN complex for ATM activation by DNA damage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
DNA damage-induced MDMX degradation is mediated by MDM2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MDM2 promotes ubiquitination and degradation of MDMX
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Aberrant expression of HDMX proteins in tumor cells correlates with wild-type p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Substrate specificities and identification of putative substrates of ATM kinase family members
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MDM2 interacts with MDMX through their RING finger domains
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
The MDM2 gene amplification database
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
MDMX: a novel p53-binding protein with some functional properties of MDM2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
28 May 2018
TP53 pathway analysis in paediatric Burkitt lymphoma reveals increased MDM4 expression as the only TP53 pathway abnormality detected in a subset of cases.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
16 August 2018
Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4160436
retrieved
16 August 2018
Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FONC.2014.27
retrieved
31 March 2020
Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24608433
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1038/ONC.2014.27
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
Dimensions Publication ID
1007181341
0 references
PMC publication ID
4160436
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
PubMed publication ID
24608433
1 reference
stated in
Europe PubMed Central
PMC publication ID
4160436
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24608433%20AND%20SRC:MED&resulttype=core&format=json
retrieved
10 March 2020
ResearchGate publication ID
260645637
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
