(Q42626126)

4 November 2017

pH dependence of tryptophan synthase catalytic mechanism: I. The first stage, the beta-elimination reaction (English)

1 reference

4 November 2017

Stefano Bettati

2

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Cristiano Viappiani

object named as

Cristiano Viappiani

series ordinal

3

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Andrea Mozzarelli

object named as

Andrea Mozzarelli

series ordinal

4

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author name string

Francesca Schiaretti

series ordinal

1

1 reference

PubMed ID

15117965

4 November 2017

language of work or name

English

0 references

publication date

26 April 2004

1 reference

Journal of Biological Chemistry

4 November 2017

1 reference

4 November 2017

279

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4 November 2017

28

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4 November 2017

29572-29582

1 reference

Protein architecture, dynamics and allostery in tryptophan synthase channeling

4 November 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

The tryptophan synthase bienzyme complex transfers indole between the alpha- and beta-sites via a 25-30 A long tunnel

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Allosteric interactions coordinate catalytic activity between successive metabolic enzymes in the tryptophan synthase bienzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Characterization of the functional role of a flexible loop in the alpha-subunit of tryptophan synthase from Salmonella typhimurium by rapid-scanning, stopped-flow spectroscopy and site-directed mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Allosteric communication in the tryptophan synthase bienzyme complex: roles of the beta-subunit aspartate 305-arginine 141 salt bridge

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Loop closure and intersubunit communication in tryptophan synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Allosteric communication of tryptophan synthase. Functional and regulatory properties of the beta S178P mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Detection of open and closed conformations of tryptophan synthase by 15N-heteronuclear single-quantum coherence nuclear magnetic resonance of bound 1-15N-L-tryptophan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Kinetic studies of tryptophan synthetase. Interaction of substrates with the B subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Fluorescence studies of substrate and subunit interactions of the .beta.2 protein of Escherichia coli tryptophan synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Time-resolved fluorescence of tryptophan synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Detection and identification of intermediates in the reaction of L-serine with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Monovalent cations affect dynamic and functional properties of the tryptophan synthase alpha 2 beta 2 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Proton transfers in the beta-reaction catalyzed by tryptophan synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Reaction of indole and analogues with amino acid complexes of Escherichia coli tryptophan indole-lyase: detection of a new reaction intermediate by rapid-scanning stopped-flow spectrophotometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Identification and spectral characterization of the external aldimine of the O-acetylserine sulfhydrylase reaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Monovalent metal ions play an essential role in catalysis and intersubunit communication in the tryptophan synthase bienzyme complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Interactions between the Subunits of the Tryptophan Synthetase of Escherichia coli. Optical Properties of an Intermediate Bound to the α2β2 Complex*

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Effect of pH and Monovalent Cations on the Formation of Quinonoid Intermediates of the Tryptophan Synthase α2β2Complex in Solution and in the Crystal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Catalytic mechanism of the tryptophan synthase alpha(2)beta(2) complex. Effects of pH, isotopic substitution, and allosteric ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Structure and function of the tryptophan synthase alpha(2)beta(2) complex. Roles of beta subunit histidine 86.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Allosteric regulation of tryptophan synthase: effects of pH, temperature, and alpha-subunit ligands on the equilibrium distribution of pyridoxal 5'-phosphate-L-serine intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Mechanisms of monovalent cation action in enzyme catalysis: the first stage of the tryptophan synthase beta-reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Mechanisms of monovalent cation action in enzyme catalysis: the tryptophan synthase alpha-, beta-, and alpha beta-reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Exchange of K+ or Cs+ for Na+ induces local and long-range changes in the three-dimensional structure of the tryptophan synthase alpha2beta2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Crystal structure of the beta Ser178--> Pro mutant of tryptophan synthase. A "knock-out" allosteric enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Novel allosteric effectors of the tryptophan synthase alpha(2)beta(2) complex identified by computer-assisted molecular modeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

PCR mutagenesis and overexpression of tryptophan synthase from Salmonella typhimurium: on the roles of beta2 subunit Lys-382.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Catalytic roles of divalent metal ions in phosphoryl transfer by EcoRV endonuclease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

HINT: a new method of empirical hydrophobic field calculation for CoMFA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Hydrophobicity: is LogP(o/w) more than the sum of its parts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Very empirical treatment of solvation and entropy: a force field derived from log Po/w

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 1. Models without explicit constrained water

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Simple, intuitive calculations of free energy of binding for protein-ligand complexes. 2. Computational titration and pH effects in molecular models of neuraminidase-inhibitor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Computationally accessible method for estimating free energy changes resulting from site-specific mutations of biomolecules: systematic model building and structural/hydropathic analysis of deoxy and oxy hemoglobins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Computational methodology for estimating changes in free energies of biomolecular association upon mutation. The importance of bound water in dimer-tetramer assembly for beta 37 mutant hemoglobins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Proanthocyanidins in health care: current and new trends

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Characterization of the reaction of L-serine and indole with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Crystal structures of a new class of allosteric effectors complexed to tryptophan synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

The origin of multiply sigmoid curves of pH-dependence. The partitioning of groups among titration pK values

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Structural basis for the impaired channeling and allosteric inter-subunit communication in the beta A169L/beta C170W mutant of tryptophan synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the beta-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M401895200

21 January 2018

Identifiers

DOI

10.1074/JBC.M401895200

1 reference

4 November 2017

1 reference

PubMed ID

15117965