(Q42695021)

English

Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death

scientific article published on 13 December 2012

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scholarly article

1 reference

Europe PubMed Central

5 November 2017

Chemotherapeutic induction of mitochondrial oxidative stress activates GSK-3α/β and Bax, leading to permeability transition pore opening and tumor cell death (English)

1 reference

Europe PubMed Central

5 November 2017

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

7

1 reference

Europe PubMed Central

5 November 2017

8

1 reference

Europe PubMed Central

5 November 2017

Andrea Trevisan

9

1 reference

Europe PubMed Central

5 November 2017

author name string

F Chiara

1

1 reference

Europe PubMed Central

5 November 2017

A Gambalunga

2

1 reference

Europe PubMed Central

5 November 2017

M Sciacovelli

3

1 reference

Europe PubMed Central

5 November 2017

A Nicolli

4

1 reference

Europe PubMed Central

5 November 2017

L Ronconi

5

1 reference

Europe PubMed Central

5 November 2017

D Fregona

6

1 reference

Europe PubMed Central

5 November 2017

publication date

13 December 2012

1 reference

Europe PubMed Central

5 November 2017

Cell Death and Disease

1 reference

Europe PubMed Central

5 November 2017

3

1 reference

Europe PubMed Central

5 November 2017

e444

1 reference

Europe PubMed Central

5 November 2017

https://scigraph.springernature.com/pub.10.1038/cddis.2012.184

0 references

Induction of the permeability transition pore in cells depleted of mitochondrial DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

GSK-3: Functional Insights from Cell Biology and Animal Models

1 reference

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27 May 2018

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

1 reference

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27 May 2018

SCaMC-1 promotes cancer cell survival by desensitizing mitochondrial permeability transition via ATP/ADP-mediated matrix Ca(2+) buffering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

1 reference

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27 May 2018

Intracellular zinc release-activated ERK-dependent GSK-3β-p53 and Noxa-Mcl-1 signaling are both involved in cardiac ischemic-reperfusion injury

1 reference

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27 May 2018

Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis

1 reference

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27 May 2018

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

1 reference

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Hallmarks of Cancer: The Next Generation

1 reference

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27 May 2018

Regulation of cancer cell metabolism

1 reference

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The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

1 reference

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27 May 2018

Redox metabolism and malignancy

1 reference

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The architecture of respiratory complex I

1 reference

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27 May 2018

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

1 reference

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27 May 2018

Antitumor activity of gold(III)-dithiocarbamato derivatives on prostate cancer cells and xenografts

1 reference

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27 May 2018

Signal transduction to the permeability transition pore.

1 reference

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27 May 2018

Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition

1 reference

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27 May 2018

The Midas touch in cancer chemotherapy: from platinum- to gold-dithiocarbamato complexes.

1 reference

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27 May 2018

THE METABOLISM OF TUMORS IN THE BODY

1 reference

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27 May 2018

p53 and metabolism

1 reference

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27 May 2018

Mitochondrial calcium and the permeability transition in cell death

1 reference

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27 May 2018

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

Mitochondrial respiratory complex I: structure, function and implication in human diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells

1 reference

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27 May 2018

Mitochondria in cancer: not just innocent bystanders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

How mitochondria produce reactive oxygen species

1 reference

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27 May 2018

Bcl-2 family proteins and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

Cancer cell metabolism: Warburg and beyond

1 reference

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27 May 2018

Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

The BCL-2 protein family: opposing activities that mediate cell death

1 reference

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Mitochondria and cellular oxygen sensing in the HIF pathway.

1 reference

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27 May 2018

Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

1 reference

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27 May 2018

Gold(III)-dithiocarbamato complexes induce cancer cell death triggered by thioredoxin redox system inhibition and activation of ERK pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3542620

27 May 2018

ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis

1 reference

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RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

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27 May 2018

The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis

1 reference

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A chaperone-dependent GSK3beta transitional intermediate mediates activation-loop autophosphorylation

1 reference

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The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

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1 reference

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Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt.

1 reference

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Mitochondrial ROS-induced ROS release: an update and review

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27 May 2018

Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism

1 reference

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On the Origin of Cancer Cells

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The Hallmarks of Cancer

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Regulation of the permeability transition pore in skeletal muscle mitochondria. Modulation By electron flow through the respiratory chain complex i.

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Inactivation of p53 gene in human and murine osteosarcoma cells

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GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.

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Glycogen synthase kinase-3beta activity plays very important roles in determining the fate of oxidative stress-inflicted neuronal cells.

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/CDDIS.2012.184

1 reference

Europe PubMed Central

5 November 2017

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1 reference

Europe PubMed Central

5 November 2017

1 reference

Europe PubMed Central

5 November 2017

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