(Q42700256)

English

Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function

scientific article published on March 2011

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Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Systematic biochemical analysis of somatic missense mutations in DNA polymerase β found in prostate cancer reveal alteration of enzymatic function (English)

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

author name string

Chang Long An

1

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Desheng Chen

2

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

Nick M Makridakis

3

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

publication date

1 March 2011

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

32

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

4

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

415-423

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

DNA polymerase beta is critical for mouse meiotic synapsis

1 reference

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27 May 2018

A platinum agent resistance gene, POLB, is a prognostic indicator in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Genomic analysis of cancer tissue reveals that somatic mutations commonly occur in a specific motif.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

No association between the SRD5A2 gene A49T missense variant and prostate cancer risk: lessons learned

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

The Leu22Pro tumor-associated variant of DNA polymerase beta is dRP lyase deficient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Is base excision repair a tumor suppressor mechanism?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Analysis of bgl operon structure and characterization of beta-glucosidase from Pectobacterium carotovorum subsp. carotovorum LY34.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Is there a link between DNA polymerase beta and cancer?

1 reference

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27 May 2018

Dynamic characterization of a DNA repair enzyme: NMR studies of [methyl-13C]methionine-labeled DNA polymerase beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

A DNA polymerase beta mutant from colon cancer cells induces mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

DNA damage and repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

A role for DNA polymerase beta in mutagenic UV lesion bypass

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Error-prone repair DNA polymerases in prokaryotes and eukaryotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Efficient processing of DNA ends during yeast nonhomologous end joining. Evidence for a DNA polymerase beta (Pol4)-dependent pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

3'-Azido-3'-deoxythymidine-resistant mutants of DNA polymerase beta identified by in vivo selection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Crystal structures of human DNA polymerase beta complexed with DNA: implications for catalytic mechanism, processivity, and fidelity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

DNA polymerase beta gene mutation in human prostate cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

In vivo amplification of the androgen receptor gene and progression of human prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Differential gene expression in human cancer cells resistant to cisplatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

27 May 2018

Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

16 August 2018

Base excision repair deficiency caused by polymerase beta haploinsufficiency: accelerated DNA damage and increased mutational response to carcinogens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

16 August 2018

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

16 August 2018

Increased activity and fidelity of DNA polymerase beta on single-nucleotide gapped DNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3060284

16 August 2018

Genetic variation in the DNA repair genes is predictive of outcome in lung cancer

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21465

21 January 2018

Polymorphisms in Genes of Nucleotide and Base Excision Repair: Risk and Prognosis of Colorectal Cancer

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.21465

21 January 2018

Structural insights into DNA polymerase beta fidelity: hold tight if you want it right

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human DNA polymerase beta deoxyribose phosphate lyase. Substrate specificity and catalytic mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of phenylalanine 272 of DNA polymerase beta in discriminating between correct and incorrect deoxynucleoside triphosphates

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostate cancer risk assessment program. A model for the early detection of prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prostate-cancer-associated I260M variant of DNA polymerase beta is a sequence-specific mutator

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The D246V mutant of DNA polymerase beta misincorporates nucleotides: evidence for a role for the flexible loop in DNA positioning within the active site

1 reference

https://pubmed.ncbi.nlm.nih.gov/21305655

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/HUMU.21465

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

5 November 2017

ResearchGate publication ID

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