(Q42806263)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12531896%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

title

The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase (English)

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16 December 2019

5

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16 December 2019

Pierre Hainaut

6

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16 December 2019

author name string

Olivier Pluquet

1

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16 December 2019

Sophie North

2

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16 December 2019

Anindita Bhoumik

3

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16 December 2019

Konstantinos Dimas

4

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16 December 2019

language of work or name

English

0 references

publication date

16 January 2003

1 reference

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Journal of Biological Chemistry

16 December 2019

published in

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16 December 2019

volume

278

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16 December 2019

issue

14

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16 December 2019

page(s)

11879-11887

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Amifostine pretreatment for protection against cyclophosphamide-induced and cisplatin-induced toxicities: results of a randomized control trial in patients with advanced ovarian cancer

16 December 2019

cites work

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The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine (Ethyol).

21 January 2018

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Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines

21 January 2018

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Repression of c-myc gene expression by the thiol and disulfide forms of the cytoprotector amifostine

21 January 2018

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Amifostine (WR2721) restores transcriptional activity of specific p53 mutant proteins in a yeast functional assay

21 January 2018

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Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1.

21 January 2018

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The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway.

21 January 2018

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p53, the cellular gatekeeper for growth and division

21 January 2018

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Genotoxic and non-genotoxic pathways of p53 induction

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Activation and activities of the p53 tumour suppressor protein

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Multiple roles of the tumor suppressor p53.

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Mdm2 association with p53 targets its ubiquitination

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JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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Regulation of p53 stability by Mdm2

21 January 2018

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Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

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The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

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The evolution of diverse biological responses to DNA damage: insights from yeast and p53.

21 January 2018

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Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

21 January 2018

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Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

21 January 2018

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p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

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DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

21 January 2018

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SUMO-1 modification activates the transcriptional response of p53

21 January 2018

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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The DNA-dependent protein kinase

21 January 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

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Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

21 January 2018

1 reference

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Sounding the alarm: protein kinase cascades activated by stress and inflammation

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

21 January 2018

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c-Jun NH2-terminal kinases target the ubiquitination of their associated transcription factors

21 January 2018

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Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding

21 January 2018

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p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts

21 January 2018

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

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New colorimetric cytotoxicity assay for anticancer-drug screening

21 January 2018

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Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines

21 January 2018

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Regulation of p53 by metal ions and by antioxidants: dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper.

21 January 2018

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Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome.

21 January 2018

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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MEKK1/JNK signaling stabilizes and activates p53.

21 January 2018

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DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

21 January 2018

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Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate

21 January 2018

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c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells

21 January 2018

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c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylase

21 January 2018

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Regulation of p53 in response to DNA damage

21 January 2018

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Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721

21 January 2018

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Amifostine (WR-2721) Protects Normal Haematopoietic Stem Cells Against Cyclophosphamide Derivatives' Toxicity Without Compromising Their Antileukaemic Effects

21 January 2018

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Protection of mouse bone marrow by WR-2721 after fractionated irradiation

21 January 2018

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Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate

21 January 2018

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Amifostine, cisplatin, and vinblastine in metastatic non-small-cell lung cancer: a report of high response rates and prolonged survival

21 January 2018

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Effects of the modulating agent WR2721 on myelotoxicity and antitumour activity in carboplatin-treated mice

21 January 2018

1 reference

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Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action

21 January 2018

1 reference

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Degradation of 2-(3-aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of chinese hamster ovary cells

21 January 2018

1 reference

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JNK (c-Jun NH2-terminal kinase) is a target for antioxidants in T lymphocytes

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M207396200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12531896%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference