(Q42810049)

English

Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt)

scientific article published on November 16, 2010

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Europe PubMed Central

PubMed publication ID

7 November 2017

Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt) (English)

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

1 reference

based on heuristic

inferred from title

Tracey C Fleischer

11

object named as

Tracey C. Fleischer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A21080724

27 August 2024

author name string

Zhong-Hua Gao

6

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7 November 2017

Kirill Ostanin

7

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7 November 2017

Jeremy Green

8

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7 November 2017

Rena McKinnon

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7 November 2017

Mark Shenderovich

13

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7 November 2017

Jeffrey W. Lockman

1

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27 August 2024

Brett R. Murphy

2

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27 August 2024

Daniel F. Zigar

3

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27 August 2024

Weston R. Judd

4

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27 August 2024

Paul M. Slattum

5

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27 August 2024

Ryan T. Terry-Lorenzo

10

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27 August 2024

J. Jay Boniface

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27 August 2024

J. Adam Willardsen

14

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27 August 2024

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publication date

16 November 2010

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7 November 2017

full work available at URL

https://pubs.acs.org/doi/pdf/10.1021/jm101145b

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10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

Journal of Medicinal Chemistry

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7 November 2017

53

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7 November 2017

24

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Europe PubMed Central

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7 November 2017

8734-8746

1 reference

Europe PubMed Central

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7 November 2017

A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus

2

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action

3

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

The design and synthesis of water-soluble analogues of CB30865, a quinazolin-4-one-based antitumor agent

4

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound

5

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

Nampt: linking NAD biology, metabolism and cancer

6

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

The nicotinamide phosphoribosyltransferase: a molecular link between metabolism, inflammation, and cancer

7

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity

8

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery

9

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

10

1 reference

10.1021/JM101145B

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27 August 2024

Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study

12

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry

14

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.

15

1 reference

10.1021/JM101145B

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27 August 2024

Crystal structure of Rattus norvegicus Visfatin/PBEF/Nampt in complex with an FK866-based inhibitor

16

1 reference

10.1021/JM101145B

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27 August 2024

Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency

17

1 reference

10.1021/JM101145B

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27 August 2024

N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid

18

1 reference

10.1021/JM101145B

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27 August 2024

Diphenylphosphoryl azide. A new convenient reagent for a modified Curtus reaction and for the peptide synthesis

19

1 reference

10.1021/JM101145B

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27 August 2024

Efficient access to azaindoles and indoles

20

1 reference

10.1021/JM101145B

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27 August 2024

5-Arylthio-substituted 2-amino-4-oxo-6-methylpyrrolo[2,3-d]pyrimidine antifolates as thymidylate synthase inhibitors and antitumor agents

21

1 reference

10.1021/JM101145B

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27 August 2024

2-amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines as nonclassical antifolate inhibitors of thymidylate synthase

22

1 reference

10.1021/JM101145B

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27 August 2024

Dual inhibitors of thymidylate synthase and dihydrofolate reductase as antitumor agents: design, synthesis, and biological evaluation of classical and nonclassical pyrrolo[2,3-d]pyrimidine antifolates(1)

23

1 reference

10.1021/JM101145B

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27 August 2024

Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihy

24

1 reference

10.1021/JM101145B

https://api.crossref.org/works/10.1021/JM101145B

27 August 2024

Identifiers

10.1021/JM101145B

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 November 2017

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