(Q42825258)

English

Dichotomy in NF-kappaB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering

scientific article published on 28 June 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 November 2017

Dichotomy in NF-kappaB signaling and chemoresistance in immunoglobulin variable heavy-chain-mutated versus unmutated CLL cells upon CD40/TLR9 triggering (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

toll-like receptor

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author name string

J M Tromp

1

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Europe PubMed Central

PubMed publication ID

8 November 2017

S H Tonino

2

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Europe PubMed Central

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8 November 2017

J A Elias

3

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Europe PubMed Central

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8 November 2017

A Jaspers

4

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Europe PubMed Central

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8 November 2017

D M Luijks

5

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Europe PubMed Central

PubMed publication ID

8 November 2017

A P Kater

6

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Europe PubMed Central

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8 November 2017

R A W van Lier

7

1 reference

Europe PubMed Central

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8 November 2017

M H J van Oers

8

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8 November 2017

E Eldering

9

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8 November 2017

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publication date

28 June 2010

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Europe PubMed Central

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8 November 2017

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8 November 2017

29

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8 November 2017

36

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8 November 2017

5071-5082

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Europe PubMed Central

PubMed publication ID

8 November 2017

https://scigraph.springernature.com/pub.10.1038/onc.2010.248

0 references

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

1 reference

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B cell response to surface IgM cross-linking identifies different prognostic groups of B-chronic lymphocytic leukemia patients

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21 January 2018

Role of the microenvironment in chronic lymphocytic leukaemia

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31 March 2020

Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease?

1 reference

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31 March 2020

ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia

1 reference

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31 March 2020

Cell proliferation and death: forgotten features of chronic lymphocytic leukemia B cells

1 reference

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31 March 2020

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

1 reference

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31 March 2020

B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes

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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

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Effect of immunostimulatory CpG-oligonucleotides in chronic lymphocytic leukemia B cells

1 reference

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31 March 2020

BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors.

1 reference

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31 March 2020

Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells

1 reference

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31 March 2020

Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia

1 reference

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31 March 2020

c-Abl kinase inhibitors overcome CD40-mediated drug resistance in CLL: implications for therapeutic targeting of chemoresistant niches

1 reference

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31 March 2020

Shared principles in NF-kappaB signaling

1 reference

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31 March 2020

The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target

1 reference

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31 March 2020

Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis

1 reference

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31 March 2020

CD40 stimulation of B-cell chronic lymphocytic leukaemia cells enhances the anti-apoptotic profile, but also Bid expression and cells remain susceptible to autologous cytotoxic T-lymphocyte attack.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

Frequent inactivation of A20 in B-cell lymphomas

1 reference

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31 March 2020

The B-cell receptor and ZAP-70 in chronic lymphocytic leukemia

1 reference

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31 March 2020

Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells.

1 reference

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31 March 2020

Immunotherapeutic uses of CpG oligodeoxynucleotides

1 reference

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31 March 2020

NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

The Akt signaling pathway determines the different proliferative capacity of chronic lymphocytic leukemia B-cells from patients with progressive and stable disease.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

p65 activity and ZAP-70 status predict the sensitivity of chronic lymphocytic leukemia cells to the selective IkappaB kinase inhibitor BMS-345541.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

Microenvironmental interactions and survival of CLL B-cells

1 reference

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31 March 2020

Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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31 March 2020

Molecular and cellular mechanisms of CLL: novel therapeutic approaches.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

Toll-like receptors, endogenous ligands, and systemic autoimmune disease.

1 reference

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31 March 2020

Variability in the Degree of Expression of Phosphorylated I B in Chronic Lymphocytic Leukemia Cases With Nodal Involvement

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

The role of APRIL and BAFF in lymphocyte activation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

Regulation of TNFRSF and innate immune signalling complexes by TRAFs and cIAPs

1 reference

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31 March 2020

The role of ubiquitin in NF-kappaB regulatory pathways.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.248

31 March 2020

Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity

1 reference

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31 March 2020

New insights into NF-kappaB regulation and function

1 reference

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31 March 2020

Noncanonical NF-kappaB signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation.

1 reference

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31 March 2020

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

1 reference

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31 March 2020

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

1 reference

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31 March 2020

In vivo dynamics of stable chronic lymphocytic leukemia inversely correlate with somatic hypermutation levels and suggest no major leukemic turnover in bone marrow.

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31 March 2020

Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia

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31 March 2020

Plasma interleukin 8 level predicts for survival in chronic lymphocytic leukaemia

1 reference

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CD154 induces a switch in pro-survival Bcl-2 family members in chronic lymphocytic leukaemia.

1 reference

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31 March 2020

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

1 reference

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31 March 2020

Biology and treatment of chronic lymphocytic leukemia

1 reference

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7 January 2021

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10.1038/ONC.2010.248

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 November 2017

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