(Q42916637)

English

Variants in the Dihydropyrimidine Dehydrogenase, Methylenetetrahydrofolate Reductase and Thymidylate Synthase Genes Predict Early Toxicity of 5-Fluorouracil in Colorectal Cancer Patients

scientific article published on May 1, 2010

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scholarly article

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Europe PubMed Central

PubMed publication ID

11 November 2017

Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Variants in the Dihydropyrimidine Dehydrogenase, Methylenetetrahydrofolate Reductase and Thymidylate Synthase Genes Predict Early Toxicity of 5-Fluorouracil in Colorectal Cancer Patients (English)

1 reference

10.1177/147323001003800313

https://api.crossref.org/works/10.1177/147323001003800313

7 July 2024

colorectal cancer

1 reference

based on heuristic

inferred from title

colorectal carcinoma

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Palle Lyngsie Pedersen

2

object named as

P. L. Pedersen

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819423

7 July 2024

author name string

M. H. Kristensen

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819423

7 July 2024

G. V. Melsen

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819423

7 July 2024

J. Ellehauge

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819423

7 July 2024

J. Mejer

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20819423

7 July 2024

language of work or name

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based on heuristic

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publication date

1 May 2010

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

full work available at URL

http://journals.sagepub.com/doi/pdf/10.1177/147323001003800313

1 reference

10.1177/147323001003800313

https://api.crossref.org/works/10.1177/147323001003800313

7 July 2024

Journal of International Medical Research

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

38

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

870-883

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors.

1 reference

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21 January 2018

Fluorinated pyrimidines, a new class of tumour-inhibitory compounds

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration

1 reference

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21 January 2018

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity

1 reference

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21 January 2018

Capecitabine: effective oral fluoropyrimidine chemotherapy

1 reference

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21 January 2018

Toxic death-case after capecitabine + oxaliplatin (XELOX) administration: probable implication of dihydropyrimidine deshydrogenase deficiency

1 reference

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21 January 2018

Prediction of clinical outcome of fluoropyrimidine-based chemotherapy for gastric cancer patients, in terms of the 5-fluorouracil metabolic pathway

1 reference

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21 January 2018

Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy

1 reference

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21 January 2018

Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy

1 reference

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21 January 2018

Genetic determinants of cancer drug efficacy and toxicity: practical considerations and perspectives

1 reference

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21 January 2018

A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels

1 reference

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21 January 2018

Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate

1 reference

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21 January 2018

Methylenetetrahydrofolate reductase gene polymorphisms and response to fluorouracil-based treatment in advanced colorectal cancer patients.

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity

1 reference

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21 January 2018

A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase

1 reference

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21 January 2018

Effect of 5,10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism

1 reference

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21 January 2018

Novel disease-causing mutations in the dihydropyrimidine dehydrogenase gene interpreted by analysis of the three-dimensional protein structure

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W

1 reference

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21 January 2018

Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer

1 reference

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21 January 2018

Differences in toxicity between men and women treated with 5-fluorouracil therapy for colorectal carcinoma

1 reference

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21 January 2018

Delayed oxaliplatin-associated neurotoxicity following adjuvant chemotherapy for stage III colon cancer

1 reference

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21 January 2018

Oxaliplatin-safety profile: neurotoxicity

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Oxaliplatin-related neurotoxicity: interest of calcium-magnesium infusion and no impact on its efficacy

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasian and Asian populations.

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer

1 reference

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21 January 2018

A comparative analysis of translated dihydropyrimidine dehydrogenase cDNA; conservation of functional domains and relevance to genetic polymorphisms

1 reference

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21 January 2018

Detailed analysis of five mutations in dihydropyrimidine dehydrogenase detected in cancer patients with 5-fluorouracil-related side effects

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in a cohort of Caucasian individuals

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Germline mutation of dihydropyrimidine dehydrogenese gene among a Japanese population in relation to toxicity to 5-Fluorouracil

1 reference

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21 January 2018

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

1 reference

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21 January 2018

Pyrimidine degradation defects and severe 5-fluorouracil toxicity

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

The influence of fluorouracil outcome parameters on tolerance and efficacy in patients with advanced colorectal cancer

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients.

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinom

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Radiochemical assay for determination of dihydropyrimidinase activity using reversed-phase high-performance liquid chromatography

1 reference

https://api.crossref.org/works/10.1177%2F147323001003800313

21 January 2018

Body composition as an independent determinant of 5-fluorouracil-based chemotherapy toxicity.

1 reference

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21 January 2018

Problems of reporting genetic associations with complex outcomes

1 reference

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21 January 2018

Advances and challenges in fluoropyrimidine pharmacogenomics and pharmacogenetics.

1 reference

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21 January 2018

Safe administration of irinotecan, oxaliplatin and raltitrexed in a DPD-deficient patient with metastatic colon cancer

1 reference

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21 January 2018

A well-tolerated 5-FU-based treatment subsequent to severe capecitabine-induced toxicity in a DPD-deficient patient

1 reference

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21 January 2018

Familial pyrimidinemia and pyrimidinuria associated with severe fluorouracil toxicity

6

1 reference

10.1177/147323001003800313

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Long-term weekly treatment of colorectal metastatic cancer with fluorouracil and leucovorin: results of a multicentric prospective trial of fluorouracil dosage optimization by pharmacokinetic monitoring in 152 patients

8

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7 July 2024

Proceedings of the American Association for Cancer Research

20

43

660

author name string

Lenz HJ

publication date

2002

1 reference

10.1177/147323001003800313

https://api.crossref.org/works/10.1177/147323001003800313

7 July 2024

Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft

22

1 reference

10.1177/147323001003800313

https://api.crossref.org/works/10.1177/147323001003800313

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27

23

958

author name string

Lu JW

publication date

2004

1 reference

10.1177/147323001003800313

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7 July 2024

MTHFR gene polymorphism and severe toxicity during adjuvant treatment of early breast cancer with cyclophosphamide, methotrexate, and fluorouracil (CMF)

29

1 reference

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Hand-foot syndrome variant in a dihydropyrimidine dehydrogenase-deficient patient treated with capecitabine

34

1 reference

10.1177/147323001003800313

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Known variant DPYD alleles do not explain DPD deficiency in cancer patients

36

1 reference

10.1177/147323001003800313

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Rapid, simple alkaline extraction of human genomic DNA from whole blood, buccal epithelial cells, semen and forensic stains for PCR

44

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Population study of dihydropyrimidine dehydrogenase in cancer patients

48

1 reference

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Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study

55

1 reference

10.1177/147323001003800313

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7 July 2024

Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU

57

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Cardiac toxicity of 5-fluorouracil: a study on 1083 patients.

59

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Clinical and biochemical abnormalities in a patient with dihydropyrimidine dehydrogenase deficiency due to homozygosity for the C29R mutation

64

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7 July 2024

Identifiers

10.1177/147323001003800313

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

ResearchGate publication ID

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