(Q42925815)

English

p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor

scientific article published on October 2009

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

p53-Mediated down-regulation of the human DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) via interaction with Sp1 transcription factor (English)

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

author name string

Dora Bocangel

1

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Shiladitya Sengupta

2

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Sankar Mitra

3

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Kishor K Bhakat

4

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

language of work or name

0 references

publication date

1 October 2009

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

Anticancer Research

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

29

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

10

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

3741-3750

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2814523/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents

1 reference

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27 May 2018

MGMT: a personal perspective

1 reference

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Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines

1 reference

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27 May 2018

O6-methylguanine DNA methyltransferase and p53 status predict temozolomide sensitivity in human malignant glioma cells

1 reference

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27 May 2018

P53 in cancer: a paradigm for modern management of cancer

1 reference

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27 May 2018

CpG methylation-dependent repression of the human O6-methylguanine-DNA methyltransferase gene linked to chromatin structure alteration

1 reference

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Transcriptional repression mediated by the p53 tumour suppressor

1 reference

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BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis

1 reference

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Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents

1 reference

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Regulation of the human O(6)-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein-binding protein and p300.

1 reference

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Cooperative effects of genes controlling the G(2)/M checkpoint

1 reference

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Repair of O(6)-alkylguanine by alkyltransferases

1 reference

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High O6-methylguanine methyl transferase activity is frequently found in human oral cancer cells with p53 inactivation.

1 reference

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Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu.

1 reference

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Activity of O(6)-methylguanine-DNA methyltransferase in relation to p53 status and therapeutic response in ovarian cancer

1 reference

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p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents

1 reference

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p53, the cellular gatekeeper for growth and division

1 reference

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Wild-type p53 negatively regulates the expression of a microtubule-associated protein

1 reference

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Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer

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p53: puzzle and paradigm

1 reference

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27 May 2018

Wild-type p53 suppresses transcription of the human O6-methylguanine-DNA methyltransferase gene

1 reference

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Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

1 reference

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27 May 2018

Regulation of repair of alkylation damage in mammalian genomes

1 reference

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WAF1, a potential mediator of p53 tumor suppression

1 reference

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

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Localization of methylation sites in the human O6-methylguanine-DNA methyltransferase promoter: correlation with gene suppression

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Methylation-Related Chromatin Structure Is Associated with Exclusion of Transcription Factors from and Suppressed Expression of the O-6-Methylguanine DNA Methyltransferase Gene in Human Glioma Cell Lines

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27 May 2018

Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli

1 reference

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DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

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Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue

1 reference

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The relationship between O6-alkylguanine alkyltransferase activity and sensitivity to alkylation-induced sister chromatid exchanges in human lymphoblastoid cell lines.

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Heterogeneity of O6-alkylguanine-DNA alkyltransferase activity in peripheral blood lymphocytes: relationship between this activity in lymphocytes and in lymphoblastoid lines from normal controls and from patients with Hodgkin's disease or non-Hodgki

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Characterization of the promoter region of the human O6-methylguanine-DNA methyltransferase gene

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O6-methylguanine-DNA methyltransferase in human normal and tumor tissue from brain, lung, and ovary.

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Chaperone-dependent stabilization and degradation of p53 mutants

1 reference

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Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine

1 reference

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Inverse correlation between the expression of O6-methylguanine-DNA methyl transferase (MGMT) and p53 in breast cancer

1 reference

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Multifaceted resistance of gliomas to temozolomide.

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The p53 functional circuit

1 reference

https://pubmed.ncbi.nlm.nih.gov/19846904

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Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains

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Repair of O6-methylguanine in DNA by demethylation is lacking in Mer- human tumor cell strains

1 reference

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Correlation between DNA methylation and expression of O6-methylguanine-DNA methyltransferase gene in cultured human tumor cells

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Regulation of expression of the DNA repair gene O6-methylguanine-DNA methyltransferase via protein kinase C-mediated signaling

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Identifiers

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 November 2017

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