(Q46788559)

25 December 2017

title

Chaperone-dependent stabilization and degradation of p53 mutants (English)

1 reference

25 December 2017

0 references

P Muller

1

1 reference

25 December 2017

R Hrstka

2

1 reference

25 December 2017

D Coomber

3

1 reference

25 December 2017

D P Lane

4

1 reference

25 December 2017

B Vojtesek

5

1 reference

25 December 2017

language of work or name

English

0 references

publication date

28 January 2008

1 reference

25 December 2017

published in

Oncogene

1 reference

25 December 2017

volume

27

1 reference

25 December 2017

page(s)

3371-3383

1 reference

25 December 2017

issue

24

1 reference

25 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1211010

exact match

0 references

cites work

Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: a novel basis for antileukemia activity of histone deacetylase inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Quantifying specific antibody concentrations by enzyme-linked immunosorbent assay using slope correction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Loss of function and p53 protein stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Flavopiridol, an inhibitor of transcription: implications, problems and solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Rescuing the function of mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Mapping of the p53 and mdm-2 interaction domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

The ubiquitin ligase COP1 is a critical negative regulator of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Cooperation of molecular chaperones with the ubiquitin/proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Combination of the histone deacetylase inhibitor LBH589 and the hsp90 inhibitor 17-AAG is highly active against human CML-BC cells and AML cells with activating mutation of FLT-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

p53 mutation heterogeneity in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Comparison between p53 staining in tissue sections and p53 proteins levels measured by an ELISA technique

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Altered states: selectively drugging the Hsp90 cancer chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

Hsp70 interactions with the p53 tumour suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

mdm2 expression is induced by wild type p53 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

7 January 2021

The differential effects of mutant p53 alleles on advanced murine lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

7 January 2021

The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

7 January 2021

Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

7 January 2021

Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

7 January 2021

The 'wildtype' conformation of p53: epitope mapping using hybrid proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

7 January 2021

FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

7 January 2021

An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1211010

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1211010

1 reference

25 December 2017

Dimensions Publication ID

0 references

1 reference

25 December 2017