(Q28212970)

1

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L Chen

2

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C Li

3

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W Lu

4

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J Chen

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

2 November 2001

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published in

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volume

276

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issue

44

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page(s)

40583-90

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cites work

Mdm2 promotes the rapid degradation of p53

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Regulation of p53 stability by Mdm2

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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The p53-mdm-2 autoregulatory feedback loop

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An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

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Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

21 January 2018

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Gain of function mutations in p53.

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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

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An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

21 January 2018

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Hsp90 & Co. - a holding for folding

21 January 2018

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Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

21 January 2018

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Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

Depletion of p185erbB2, Raf-1 and mutant p53 proteins by geldanamycin derivatives correlates with antiproliferative activity

21 January 2018

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Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein

21 January 2018

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Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell

21 January 2018

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Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

21 January 2018

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Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

21 January 2018

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

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Mapping of the p53 and mdm-2 interaction domains

21 January 2018

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

Temperature-sensitive mutants of p53 homologs

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

Induction of Mdm2 and enhancement of cell survival by bFGF.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

Activation of an MDM2-specific caspase by p53 in the absence of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M102817200

The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M102817200