(Q42927518)

English

The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes

scientific article published on November 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes (English)

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

molecular chaperones

0 references

object named as

Shaoping Zhang

3

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

8

object named as

Kerry M Loomes

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

5

object named as

Anthony Hickey

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

author name string

Vita Chien

1

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Jacqueline F Aitken

2

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Christina M Buchanan

4

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Thomas Brittain

6

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

language of work or name

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publication date

1 November 2010

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Europe PubMed Central

PubMed publication ID

11 November 2017

Biochemical Journal

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Europe PubMed Central

PubMed publication ID

11 November 2017

432

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Europe PubMed Central

PubMed publication ID

11 November 2017

1

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Europe PubMed Central

PubMed publication ID

11 November 2017

113-121

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Secretion of islet amyloid polypeptide in response to glucose

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Co-secretion of amylin and insulin from cultured islet β-cells: Modulation by nutrient secretagogues, islet hormones and hypoglycemic agents

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Localisation of islet amyloid peptide in lipofuscin bodies and secretory granules of human B-cells and in islets of type-2 diabetic subjects

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Islet amyloid polypeptide: pinpointing amino acid residues linked to amyloid fibril formation

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Prevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Ultrastructural evidence that apoptosis is the mechanism by which human amylin evokes death in RINm5F pancreatic islet beta-cells.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Increased beta-cell apoptosis prevents adaptive increase in beta-cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Fibrillogenic amylin evokes islet beta-cell apoptosis through linked activation of a caspase cascade and JNK1.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Fibrillar islet amyloid polypeptide differentially affects oxidative mechanisms and lipoprotein uptake in correlation with cytotoxicity in two insulin-producing cell lines

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic mice

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Unfolding the role of protein misfolding in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Modulation of neurodegeneration by molecular chaperones

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed beta-amyloid in neurons.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Molecular chaperone functions of heat-shock proteins

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

The Hsp70 and Hsp60 chaperone machines

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Islet amyloid: phase partitioning and secondary nucleation are central to the mechanism of fibrillogenesis.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Suppression by polycyclic compounds of the conversion of human amylin into insoluble amyloid.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Identification of a novel human islet amyloid polypeptide beta-sheet domain and factors influencing fibrillogenesis

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Mechanism of thioflavin T binding to amyloid fibrils.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Mutant Cu/Zn-superoxide dismutase proteins have altered solubility and interact with heat shock/stress proteins in models of amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Roles of molecular chaperones in cytoplasmic protein folding

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Fas-associated death receptor signaling evoked by human amylin in islet beta-cells

1 reference

https://api.crossref.org/works/10.1042%2FBJ20100434

21 January 2018

Identifiers

10.1042/BJ20100434

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

11 November 2017

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