(Q43120344)

14 November 2017

Lysine conservation and context in TGFbeta and Wnt signaling suggest new targets and general themes for posttranslational modification (English)

1 reference

14 November 2017

Charlotte E Konikoff

1

1 reference

PMCID

2688696

14 November 2017

Robert G Wisotzkey

series ordinal

2

1 reference

PMCID

2688696

14 November 2017

Stuart J Newfeld

series ordinal

3

1 reference

14 November 2017

17 September 2008

1 reference

Journal of Molecular Evolution

14 November 2017

1 reference

14 November 2017

67

1 reference

14 November 2017

4

1 reference

14 November 2017

323-333

1 reference

https://scigraph.springernature.com/pub.10.1007/s00239-008-9159-4

14 November 2017

0 references

cites work

The type I TGF-beta receptor is covalently modified and regulated by sumoylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Wnt and TGF-beta expression in the sponge Amphimedon queenslandica and the origin of metazoan embryonic patterning

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Å resolution

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

The DIX domain of Dishevelled confers Wnt signaling by dynamic polymerization

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

A novel function of Drosophila eIF4A as a negative regulator of Dpp/BMP signalling that mediates SMAD degradation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

An extended consensus motif enhances the specificity of substrate modification by SUMO

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Impact of the N-terminal amino acid on targeted protein degradation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Early evolution of animal cell signaling and adhesion genes

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

A genomic and functional inventory of deubiquitinating enzymes

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Repression of Smad4 transcriptional activity by SUMO modification

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

The deubiquitinating enzyme Fam interacts with and stabilizes beta-catenin

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Identification of chromosomal regions involved in decapentaplegic function in Drosophila

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Signaling activity of transforming growth factor beta type II receptors lacking specific domains in the cytoplasmic region

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Genomic clocks and evolutionary timescales.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Multiple TGF-beta receptor related genes in sponge and ancient gene duplications before the parazoan-eumetazoan split.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2688696

Function of the two Xenopus smad4s in early frog development

15 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18797952

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Changing venues for tumour suppression: balancing destruction and localization by monoubiquitylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18797952

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18797952

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S00239-008-9159-4

1 reference

14 November 2017

1 reference

14 November 2017

1 reference

PMCID

2688696