(Q43129657)

English

Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.

scientific article published on 2 January 2009

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scholarly article

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Europe PubMed Central

PMC publication ID

14 November 2017

Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. (English)

1 reference

Europe PubMed Central

PMC publication ID

14 November 2017

toll-like receptor

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8

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14 November 2017

Michael C. Ostrowski

12

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14 November 2017

14

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Peter Libby

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14 November 2017

Sudarshana M Sharma

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Sudarshana M Sharma

5

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Tracie A. Seimon

3

object named as

Tracie Seimon

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14 November 2017

author name string

Yu Sun

1

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14 November 2017

Minako Ishibashi

2

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14 November 2017

Mingsum Lee

4

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14 November 2017

Katherine A Fitzgerald

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14 November 2017

Andriy O Samokhin

7

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14 November 2017

Scott Sayers

9

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14 November 2017

Masanori Aikawa

10

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14 November 2017

W Gray Jerome

11

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14 November 2017

Dieter Bromme

13

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14 November 2017

Ira A Tabas

15

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14 November 2017

Carrie L Welch

16

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14 November 2017

Alan R Tall

17

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14 November 2017

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publication date

2 January 2009

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14 November 2017

Circulation Research

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14 November 2017

104

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14 November 2017

4

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14 November 2017

455-465

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14 November 2017

Translating molecular discoveries into new therapies for atherosclerosis

1 reference

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Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice

1 reference

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25 May 2018

Toll-like receptors in atherosclerosis

1 reference

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Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications

1 reference

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Late endosomal traffic of the epidermal growth factor receptor ensures spatial and temporal fidelity of mitogen-activated protein kinase signaling

1 reference

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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

1 reference

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HSP70 enhances macrophage phagocytosis by interaction with lipid raft-associated TLR-7 and upregulating p38 MAPK and PI3K pathways

1 reference

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Pathogen recognition and innate immunity

1 reference

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TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells

1 reference

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Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity

1 reference

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25 May 2018

Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice

1 reference

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25 May 2018

Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation

1 reference

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

1 reference

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25 May 2018

Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor

1 reference

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A PEST deletion mutant of ABCA1 shows impaired internalization and defective cholesterol efflux from late endosomes

1 reference

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25 May 2018

Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells

1 reference

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25 May 2018

Essential role of p38 mitogen-activated protein kinase in cathepsin K gene expression during osteoclastogenesis through association of NFATc1 and PU.1

1 reference

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25 May 2018

Lysosomal cysteine proteases in atherosclerosis

1 reference

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25 May 2018

Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

1 reference

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25 May 2018

Osteoclast differentiation and activation

1 reference

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25 May 2018

Rab proteins mediate Golgi transport of caveola-internalized glycosphingolipids and correct lipid trafficking in Niemann-Pick C cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680702

25 May 2018

Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680702

25 May 2018

Linking osteopetrosis and pycnodysostosis: regulation of cathepsin K expression by the microphthalmia transcription factor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680702

25 May 2018

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680702

25 May 2018

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis

1 reference

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25 May 2018

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680702

25 May 2018

A receptor-mediated pathway for cholesterol homeostasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680702

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Isolation and characterization of Chinese hamster ovary cells defective in the intracellular metabolism of low density lipoprotein-derived cholesterol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2680702

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Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice

1 reference

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Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice

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Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activat

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Aggregated LDL and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells

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Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease

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Role of Niemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol

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Lysosomal sequestration of free and esterified cholesterol from oxidized low density lipoprotein in macrophages of different species.

1 reference

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Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intracellular transport of low density lipoprotein-derived cholesterol is inhibited in Chinese hamster ovary cells cultured with 3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one

1 reference

https://pubmed.ncbi.nlm.nih.gov/19122179

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathology of the vulnerable plaque

1 reference

https://pubmed.ncbi.nlm.nih.gov/19122179

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19122179

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based on heuristic

inferred from PubMed ID database lookup

MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19122179

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Inflammation and thrombosis: the clot thickens

1 reference

https://pubmed.ncbi.nlm.nih.gov/19122179

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCRESAHA.108.182568

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Europe PubMed Central

PMC publication ID

14 November 2017

release_7wfvtskq3jga5fohghai7ka3dq

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https://api.fatcat.wiki/v0/release/7wfvtskq3jga5fohghai7ka3dq

24 November 2022

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 November 2017

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