(Q43216496)

16 November 2017

title

Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies (English)

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16 November 2017

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GeneDB

5 February 2019

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GeneDB

6 February 2019

farnesyl pyrophosphate synthase, putative

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6

Eric Oldfield

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16 November 2017

Andrea Montalvetti

1

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16 November 2017

Alexis Fernandez

2

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16 November 2017

John M Sanders

3

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16 November 2017

Subhash Ghosh

4

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16 November 2017

Erin Van Brussel

5

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16 November 2017

Roberto Docampo

7

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16 November 2017

language of work or name

English

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publication date

4 March 2003

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Journal of Biological Chemistry

16 November 2017

published in

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16 November 2017

volume

278

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16 November 2017

issue

19

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16 November 2017

page(s)

17075-17083

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Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

16 November 2017

cites work

1 reference

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Activity of bisphosphonates against Trypanosoma brucei rhodesiense

21 January 2018

1 reference

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In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii

21 January 2018

1 reference

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Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate

21 January 2018

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Overview of bisphosphonates

21 January 2018

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Developments in the therapeutic applications of bisphosphonates

21 January 2018

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Therapeutic approaches to bone diseases

21 January 2018

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Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase

21 January 2018

1 reference

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The intracellular target for the antiresorptive aminobisphosphonate drugs in Dictyostelium discoideum is the enzyme farnesyl diphosphate synthase.

21 January 2018

1 reference

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Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

21 January 2018

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A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei

21 January 2018

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

21 January 2018

1 reference

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Cloning and functional expression of a gene encoding a vacuolar-type proton-translocating pyrophosphatase from Trypanosoma cruzi.

21 January 2018

1 reference

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

21 January 2018

1 reference

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Regulation of product chain length by isoprenyl diphosphate synthases

21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

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RASMOL: biomolecular graphics for all

21 January 2018

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Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer

21 January 2018

1 reference

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Molecular analysis of prenyl chain elongating enzymes

21 January 2018

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The graphical determination of Km and Ki

21 January 2018

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Genome sequence of the human malaria parasite Plasmodium falciparum

21 January 2018

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Bisphosphonates as chemotherapeutic agents against trypanosomatid and apicomplexan parasites

21 January 2018

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Purification and characterization of recombinant human farnesyl diphosphate synthase expressed in Escherichia coli

21 January 2018

1 reference

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Bisphosphonates derived from fatty acids are potent growth inhibitors of Trypanosoma cruzi

21 January 2018

1 reference

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Structure-activity relationships of various bisphosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Highly potent geminal bisphosphonates. From pamidronate disodium (Aredia) to zoledronic acid (Zometa).

21 January 2018

1 reference

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A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction

21 January 2018

1 reference

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Vgamma2Vdelta2 T-cell receptor-mediated recognition of aminobisphosphonates

21 January 2018

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The fall and rise of sleeping sickness

21 January 2018

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Mechanisms of action of bisphosphonates

21 January 2018

1 reference

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Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis

21 January 2018

1 reference

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Mechanism of aminobisphosphonate action: characterization of alendronate inhibition of the isoprenoid pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Inhibition of bloodstream form Trypanosoma brucei gene expression by RNA interference using the pZJM dual T7 vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Studies on novel bone resorption inhibitors. II. Synthesis and pharmacological activities of fused aza-heteroarylbisphosphonate derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Inhibition of Trypanosoma brucei gene expression by RNA interference using an integratable vector with opposing T7 promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

Analog inhibitors for the pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica and their effect on culture growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210467200

21 January 2018

Identifiers

DOI

10.1074/JBC.M210467200

1 reference

release_y7fucf4qhfhdnoxwydzbvpghtu

16 November 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/y7fucf4qhfhdnoxwydzbvpghtu

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference