(Q43227515)

16 November 2017

title

A common feature-based 3D-pharmacophore model generation and virtual screening: identification of potential PfDHFR inhibitors (English)

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16 November 2017

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2

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16 November 2017

Legesse Adane

1

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16 November 2017

Vikas Sharma

series ordinal

3

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16 November 2017

publication date

1 October 2010

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Journal of Enzyme Inhibition and Medicinal Chemistry

16 November 2017

published in

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16 November 2017

volume

25

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16 November 2017

issue

5

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16 November 2017

page(s)

635-645

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DNA and RNA synthesis: antifolates

16 November 2017

cites work

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Targeting DHFR in parasitic protozoa

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Structure, dynamics, and catalytic function of dihydrofolate reductase

21 January 2018

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Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

21 January 2018

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Molecular modeling of wild-type and antifolate resistant mutant Plasmodium falciparum DHFR.

21 January 2018

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Homology modeling of wild type and pyrimethamine/cycloguanil-cross resistant mutant type Plasmodium falciparum dihydrofolate reductase. A model for antimalarial chemotherapy resistance

21 January 2018

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Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

21 January 2018

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Insights into antifolate resistance from malarial DHFR-TS structures

21 January 2018

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Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

21 January 2018

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Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.

21 January 2018

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Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum

21 January 2018

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Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum

21 January 2018

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Identification of the optimal third generation antifolate against P. falciparum and P. vivax

21 January 2018

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Conflicting requirements of Plasmodium falciparum dihydrofolate reductase mutations conferring resistance to pyrimethamine-WR99210 combination.

21 January 2018

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Virtual ligand screening: strategies, perspectives and limitations

21 January 2018

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Advances in virtual screening

21 January 2018

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Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors

21 January 2018

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Exploiting Structural Analysis, in Silico Screening, and Serendipity To Identify Novel Inhibitors of Drug-Resistant Falciparum Malaria

21 January 2018

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In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum

21 January 2018

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Pharmacophore modeling and three-dimensional database searching for drug design using catalyst

21 January 2018

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Multiple automatic base selection: protein-ligand docking based on incremental construction without manual intervention.

21 January 2018

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A fast flexible docking method using an incremental construction algorithm.

21 January 2018

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21 January 2018

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Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

21 January 2018

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

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Selection criteria for drug-like compounds

21 January 2018

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Property distribution of drug-related chemical databases.

21 January 2018

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Development and validation of a genetic algorithm for flexible docking

21 January 2018

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A general and fast scoring function for protein-ligand interactions: a simplified potential approach.

21 January 2018

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A geometric approach to macromolecule-ligand interactions

21 January 2018

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Empirical scoring functions: I. The development of a fast empirical scoring function to estimate the binding affinity of ligands in receptor complexes.

21 January 2018

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Lead-like, drug-like or "Pub-like": how different are they?

21 January 2018

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10.3109/14756360903393817

21 January 2018

Identifiers

DOI

1 reference

release_h2ikbkmihbbqddcl4bc7iypssy

16 November 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/h2ikbkmihbbqddcl4bc7iypssy

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference