(Q43239264)

17 November 2017

title

The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease (English)

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17 November 2017

3

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17 November 2017

9

Bruce Beutler

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17 November 2017

Katharina Brandl

4

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Celine Eidenschenk

2

object named as

Celine Eidenschenk

1 reference

17 November 2017

Nengming Xiao

1

1 reference

17 November 2017

Amanda L Blasius

5

1 reference

17 November 2017

Yu Xia

6

1 reference

17 November 2017

Kevin Khovananth

7

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17 November 2017

Nora G Smart

8

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17 November 2017

language of work or name

English

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publication date

1 December 2009

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17 November 2017

published in

Journal of Immunology

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17 November 2017

volume

183

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17 November 2017

issue

12

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17 November 2017

page(s)

7975-7983

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Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages

17 November 2017

cites work

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Role of bacterial DNA in macrophage activation by group B streptococci

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Tpl-2 induces IL-2 expression in T-cell lines by triggering multiple signaling pathways that activate NFAT and NF-kappaB

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Type I interferon sensitizes lymphocytes to apoptosis and reduces resistance to Listeria infection.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-β production in myeloid dendritic cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Coordinating TLR-activated signaling pathways in cells of the immune system

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Analysis of the MCMV resistome by ENU mutagenesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

CD14 is required for MyD88-independent LPS signaling.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

The yin and yang of type I interferon activity in bacterial infection

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Mitogen-activated protein kinases and NF-kappa B are involved in TNF-alpha responses to group B streptococci

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Mice lacking the type I interferon receptor are resistant to Listeria monocytogenes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Type I interferon production enhances susceptibility to Listeria monocytogenes infection

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Triggering the interferon antiviral response through an IKK-related pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Mouse strain differences in plasmacytoid dendritic cell frequency and function revealed by a novel monoclonal antibody

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Type I interferon production by nucleic acid-stimulated dendritic cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.4049/JIMMUNOL.0902718

Identifiers

DOI

10.4049/JIMMUNOL.0902718

1 reference

17 November 2017

1 reference