(Q43248871)

English

Bax/Bak-dependent, Drp1-independent Targeting of X-linked Inhibitor of Apoptosis Protein (XIAP) into Inner Mitochondrial Compartments Counteracts Smac/DIABLO-dependent Effector Caspase Activation.

scientific article published in July 2015

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26134559%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Bax/Bak-dependent, Drp1-independent Targeting of X-linked Inhibitor of Apoptosis Protein (XIAP) into Inner Mitochondrial Compartments Counteracts Smac/DIABLO-dependent Effector Caspase Activation (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26134559%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Anne Hamacher-Brady

1

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18 February 2020

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Nathan Ryan Brady

2

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18 February 2020

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1 July 2015

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18 February 2020

Journal of Biological Chemistry

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18 February 2020

290

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18 February 2020

36

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18 February 2020

22005-22018

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18 February 2020

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11 June 2022

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Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase.

1 reference

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Visualization of caspase-3-like activity in cells using a genetically encoded fluorescent biosensor activated by protein cleavage

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Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

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Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes

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Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy

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25 May 2018

XIAP impairs Smac release from the mitochondria during apoptosis.

1 reference

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BH3-only proteins: Orchestrators of apoptosis

1 reference

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Role for X-linked Inhibitor of apoptosis protein upstream of mitochondrial permeabilization

1 reference

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Spatial and temporal dynamics of mitochondrial membrane permeability waves during apoptosis

1 reference

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XIAP discriminates between type I and type II FAS-induced apoptosis

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Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

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Regulation of apoptosis by XIAP ubiquitin-ligase activity

1 reference

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Quantitative analysis of pathways controlling extrinsic apoptosis in single cells

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Elevated expression of inhibitor of apoptosis proteins in prostate cancer

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Real-time single cell analysis of Smac/DIABLO release during apoptosis

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Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis

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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

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Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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1 reference

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1 reference

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1 reference

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Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c rel

1 reference

https://pubmed.ncbi.nlm.nih.gov/26134559

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M115.643064

1 reference

Europe PubMed Central

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18 February 2020

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18 February 2020

PubMed publication ID

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Europe PubMed Central

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18 February 2020

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