(Q43615470)

English

Activation of a p53-independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine

scientific article published on 21 May 2001

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Activation of a p53-independent, sphingolipid-mediated cytolytic pathway in p53-negative mouse fibroblast cells treated with N-methyl-N-nitro-N-nitrosoguanidine (English)

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

1 reference

based on heuristic

inferred from title

mouse fibroblast

1 reference

based on heuristic

inferred from title

author name string

Yang J

1

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Duerksen-Hughes PJ

2

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

language of work or name

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publication date

21 May 2001

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

25 November 2017

276

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

29

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

27129-27135

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

Regulation of the stress response by ceramide

1 reference

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21 January 2018

Functions of ceramide in coordinating cellular responses to stress

1 reference

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21 January 2018

Sphingolipids--the enigmatic lipid class: biochemistry, physiology, and pathophysiology

1 reference

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21 January 2018

Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2.

1 reference

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21 January 2018

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1 reference

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21 January 2018

Activation of a retinoblastoma-protein-dependent pathway by sphingosine

1 reference

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21 January 2018

Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines

1 reference

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21 January 2018

Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest

1 reference

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21 January 2018

Role for ceramide in cell cycle arrest.

1 reference

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21 January 2018

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

1 reference

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21 January 2018

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1 reference

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21 January 2018

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity

1 reference

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21 January 2018

Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine

1 reference

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21 January 2018

Tumor necrosis factor- induces adhesion molecule expression through the sphingosine kinase pathway

1 reference

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21 January 2018

Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death

1 reference

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21 January 2018

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades

1 reference

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21 January 2018

Direct evidence for an important role of sphingomyelinase in ultraviolet-induced activation of c-Jun N-terminal kinase

1 reference

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21 January 2018

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway

1 reference

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21 January 2018

p53, the cellular gatekeeper for growth and division

1 reference

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21 January 2018

p53-dependent signal transduction induced by stress

1 reference

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21 January 2018

A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Keeping an old friend under control: regulation of p53 stability

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Multi-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Suppression of N-methyl-N'-nitro-N-nitrosoguanidine- and S-nitrosoglutathione-induced apoptosis by Bcl-2 through inhibiting glutathione-S-transferase pi in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Use of sphingosine as inhibitor of protein kinase C.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

JNK targets p53 ubiquitination and degradation in nonstressed cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

MEKK1/JNK signaling stabilizes and activates p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Induction of apoptosis by sphingosine-1-phosphate in human hepatoma cells is associated with enhanced expression of bax gene product

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Induction of programmed cell death in human retinoblastoma Y79 cells by C2-ceramide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stress-activated protein kinase pathways

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

A matter of life and cell death

1 reference

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21 January 2018

Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Quantitation of free sphingosine in liver by high-performance liquid chromatography

1 reference

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21 January 2018

Programmed cell death induced by ceramide

1 reference

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21 January 2018

Sphingolipids are potential heat stress signals in Saccharomyces

1 reference

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21 January 2018

Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M100729200

21 January 2018

Heat-induced elevation of ceramide in Saccharomyces cerevisiae via de novo synthesis

1 reference

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21 January 2018

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

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21 January 2018

Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M100729200

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

25 November 2017

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