(Q47786180)

5 February 2018

review article

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title

Keeping an old friend under control: regulation of p53 stability. (English)

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5 February 2018

author name string

Kubbutat MH

series ordinal

1

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5 February 2018

Vousden KH

series ordinal

2

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5 February 2018

publication date

1 June 1998

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5 February 2018

Trends in Molecular Medicine

published in

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5 February 2018

volume

4

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5 February 2018

page(s)

250-256

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5 February 2018

issue

6

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5 February 2018

p53 in signaling checkpoint arrest or apoptosis

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7 January 2021

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

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7 January 2021

Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells

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7 January 2021

Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

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7 January 2021

Proteolysis by calpains: a possible contribution to degradation of p53.

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7 January 2021

On the involvement of calpains in the degradation of the tumor suppressor protein p53

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7 January 2021

Structure and physiological function of calpains

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7 January 2021

Inhibition of the growth of WI-38 fibroblasts by benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone: evidence that cleavage of p53 by a calpain-like protease is necessary for G1 to S-phase transition

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7 January 2021

Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53

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7 January 2021

mdm2 expression is induced by wild type p53 activity

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7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

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7 January 2021

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

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7 January 2021

DNA damage induces phosphorylation of the amino terminus of p53

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7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

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7 January 2021

Dual roles of ATM in the cellular response to radiation and in cell growth control.

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7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

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7 January 2021

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

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7 January 2021

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

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7 January 2021

Identification of redox/repair protein Ref-1 as a potent activator of p53

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7 January 2021

A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

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7 January 2021

Cellular response to DNA damage from a potent carcinogen involves stabilization of p53 without induction of p21(waf1/cip1)

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7 January 2021

The tumor suppressor p53 is subject to both nuclear import and export, and both are fast, energy-dependent and lectin-inhibited

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7 January 2021

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

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7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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7 January 2021

Translational regulation of human p53 gene expression.

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7 January 2021

Participation of the human p53 3'UTR in translational repression and activation following gamma-irradiation

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7 January 2021

Negative feedback regulation of wild-type p53 biosynthesis.

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7 January 2021

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

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7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

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7 January 2021

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

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7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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7 January 2021

Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours

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7 January 2021

10.1016/S1357-4310(98)01260-X

Identifiers

DOI

1 reference

5 February 2018

PubMed ID

9679243

1 reference

5 February 2018