(Q43663687)

25 November 2017

title

Development of a physiologically based model for oseltamivir and simulation of pharmacokinetics in neonates and infants (English)

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25 November 2017

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Neil Parrott

1

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25 November 2017

Brian Davies

2

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25 November 2017

Gerhard Hoffmann

3

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25 November 2017

Annette Koerner

4

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25 November 2017

Thierry Lave

5

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25 November 2017

Eric Prinssen

6

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25 November 2017

Elizabeth Theogaraj

7

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25 November 2017

Thomas Singer

8

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25 November 2017

publication date

1 September 2011

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Clinical Pharmacokinetics

25 November 2017

published in

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25 November 2017

volume

50

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25 November 2017

issue

9

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25 November 2017

page(s)

613-623

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https://scigraph.springernature.com/pub.10.2165/11592640-000000000-00000

25 November 2017

exact match

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cites work

Pharmacokinetics of oseltamivir: an oral antiviral for the treatment and prophylaxis of influenza in diverse populations

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Practical lessons from the first outbreaks: clinical presentation, obstacles, and management strategies for severe pandemic (pH1N1) 2009 influenza pneumonitis.

21 January 2018

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Physiologically based pharmacokinetics in drug development and regulatory science: a workshop report (Georgetown University, Washington, DC, May 29-30, 2002).

21 January 2018

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Proposals for model-based paediatric medicinal development within the current European Union regulatory framework

21 January 2018

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Population pharmacokinetics of oseltamivir when coadministered with probenecid

21 January 2018

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Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin

21 January 2018

1 reference

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Surge in expression of carboxylesterase 1 during the post-neonatal stage enables a rapid gain of the capacity to activate the anti-influenza prodrug oseltamivir

21 January 2018

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Predicting the impact of physiological and biochemical processes on oral drug bioavailability

21 January 2018

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Dissolution testing as a prognostic tool for oral drug absorption: immediate release dosage forms

21 January 2018

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Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans.

21 January 2018

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Physiological parameter values for physiologically based pharmacokinetic models

21 January 2018

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A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes of soman in multiple species

21 January 2018

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Applications of physiologically based absorption models in drug discovery and development.

21 January 2018

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Tissue distribution of basic drugs: accounting for enantiomeric, compound and regional differences amongst beta-blocking drugs in rat.

21 January 2018

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Physiologically based pharmacokinetic modelling 2: predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions.

21 January 2018

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Mechanistic approaches to volume of distribution predictions: understanding the processes.

21 January 2018

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Developmental pharmacology--drug disposition, action, and therapy in infants and children

21 January 2018

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Oseltamivir dosing for influenza infection in premature neonates

21 January 2018

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Limited brain distribution of [3R,4R,5S]-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate phosphate (Ro 64-0802), a pharmacologically active form of oseltamivir, by active efflux across the blood-brain barrier mediated by organic a

21 January 2018

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The anti-influenza drug oseltamivir exhibits low potential to induce pharmacokinetic drug interactions via renal secretion-correlation of in vivo and in vitro studies.

21 January 2018

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The problems in scaling adult drug doses to children.

21 January 2018

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Prediction of drug disposition in infants and children by means of physiologically based pharmacokinetic (PBPK) modelling: theophylline and midazolam as model drugs

21 January 2018

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Development and evaluation of a generic physiologically based pharmacokinetic model for children.

21 January 2018

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Physiologically based pharmacokinetic (PBPK) modeling of caffeine and theophylline in neonates and adults: implications for assessing children's risks from environmental agents

21 January 2018

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Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children

21 January 2018

1 reference

https://api.crossref.org/works/10.2165%2F11592640-000000000-00000

Evaluation of the potential impact of pharmacokinetic differences on tissue dosimetry in offspring during pregnancy and lactation

21 January 2018

1 reference

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Physiological-model-based derivation of the adult and child pharmacokinetic intraspecies uncertainty factors for volatile organic compounds

21 January 2018

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Can we get the necessary clinical trials in children and avoid the unnecessary ones?

21 January 2018

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Gastric Emptying and Small Intestinal Transit Time in Preterm Infants: a Scintigraphic Method

21 January 2018

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Modeling interindividual variation in physiological factors used in PBPK models of humans

21 January 2018

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12 December 2020

Physiological parameters in laboratory animals and humans

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12 December 2020

Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics

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12 December 2020

Expression profiles of 50 xenobiotic transporter genes in humans and pre-clinical species: a resource for investigations into drug disposition

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12 December 2020

A novel strategy for physiologically based predictions of human pharmacokinetics

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12 December 2020

Physiologically based pharmacokinetics of cyclosporine A: extension to tissue distribution kinetics in rats and scale-up to human

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12 December 2020

10.2165/11592640-000000000-00000

Identifiers

DOI

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Dimensions Publication ID

25 November 2017

1031586524

0 references

1 reference