(Q43851391)

27 November 2017

title

Kinetic dissection of alpha 1-antitrypsin inhibition mechanism (English)

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27 November 2017

Jong-Shik Shin

1

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27 November 2017

Myeong-Hee Yu

series ordinal

2

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27 November 2017

language of work or name

English

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publication date

10 January 2002

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Journal of Biological Chemistry

27 November 2017

published in

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27 November 2017

volume

277

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27 November 2017

issue

14

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27 November 2017

page(s)

11629-11635

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The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

27 November 2017

cites work

1 reference

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What do dysfunctional serpins tell us about molecular mobility and disease?

21 January 2018

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Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

21 January 2018

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An atlas of serpin conformations.

21 January 2018

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Structural basis for serpin inhibitor activity

21 January 2018

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Major proteinase movement upon stable serpin-proteinase complex formation

21 January 2018

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Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111168200

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

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Natural protein proteinase inhibitors and their interaction with proteinases

21 January 2018

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Regulation of protein function by native metastability

21 January 2018

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A fluorescent probe study of plasminogen activator inhibitor-1. Evidence for reactive center loop insertion and its role in the inhibitory mechanism

21 January 2018

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Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

21 January 2018

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Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

21 January 2018

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Kinetic mechanism of the inhibition of cathepsin G by alpha 1-antichymotrypsin and alpha 1-proteinase inhibitor

21 January 2018

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Isolation and properties of human plasma α-1-proteinase inhibitor

21 January 2018

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Influence of the P5 residue on alpha1-proteinase inhibitor mechanism.

21 January 2018

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Insight into the mechanism of serpin-proteinase inhibition from 2D [1H-15N] NMR studies of the 69 kDa alpha 1-proteinase inhibitor Pittsburgh-trypsin covalent complex

21 January 2018

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Dependence of the kinetic parameters for elastase-catalyzed amide hydrolysis on the length of peptide substrates

21 January 2018

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The structure of a Michaelis serpin-protease complex

21 January 2018

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Effects of serpin binding on the target proteinase: global stabilization, localized increased structural flexibility, and conserved hydrogen bonding at the active site.

21 January 2018

1 reference

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The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

21 January 2018

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Evidence for an extended active center in elastase

21 January 2018

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Structural invariants in protein folding

21 January 2018

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The structure of a serpin-protease complex revealed by intramolecular distance measurements using donor-donor energy migration and mapping of interaction sites

21 January 2018

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Probing the native strain iin alpha1-antitrypsin

21 January 2018

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Metastability in the inhibitory mechanism of human alpha1-antitrypsin

21 January 2018

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Distribution of the native strain in human alpha 1-antitrypsin and its association with protease inhibitor function

21 January 2018

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Stopped flow fluorescence energy transfer measurement of the rate constants describing the reversible formation and the irreversible rearrangement of the elastase-alpha1-proteinase inhibitor complex

21 January 2018

1 reference

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Evidence that translocation of the proteinase precedes its acylation in the serpin inhibition pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111168200

The kinetic mechanism of serpin-proteinase complex formation. An intermediate between the michaelis complex and the inhibited complex

21 January 2018

1 reference

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Antichymotrypsin interaction with chymotrypsin. Intermediates on the way to inhibited complex formation

21 January 2018

1 reference

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Antichymotrypsin interaction with chymotrypsin. Reactions following encounter complex formation

21 January 2018

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Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111168200

Inhibitory mechanism of serpins. Mobility of the C-terminal region of the reactive-site loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111168200

Proteinase specificity and functional diversity in point mutants of plasminogen activator inhibitor 1

21 January 2018

1 reference

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Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of alpha 1-protease inhibitor (alpha 1-antitrypsin)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111168200

Characterization of the S'-subsite specificity of porcine pancreatic elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111168200

Converting trypsin to chymotrypsin: structural determinants of S1' specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111168200

Distortion of the active site of chymotrypsin complexed with a serpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111168200

21 January 2018

Identifiers

DOI

10.1074/JBC.M111168200

1 reference

27 November 2017

1 reference