(Q43878284)

27 November 2017

title

The PXR crystal structure: the end of the beginning (English)

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27 November 2017

1

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27 November 2017

Erin Schuetz

2

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27 November 2017

publication date

1 February 2002

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Trends in Pharmacological Sciences

27 November 2017

published in

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27 November 2017

volume

23

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27 November 2017

issue

2

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27 November 2017

page(s)

49-50

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

27 November 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

A pharmacophore for human pregnane X receptor ligands

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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https://api.crossref.org/works/10.1016%2FS0165-6147%2802%2901977-6

7 January 2021

10.1016/S0165-6147(02)01977-6

Identifiers

DOI

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27 November 2017

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