(Q43898845)

English

Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro: implications for prediction of metabolic interactions in vivo

scientific article published in February 2002

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Species differences in the metabolism of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in vitro: implications for prediction of metabolic interactions in vivo (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Malcolm D. Tingle

2

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

James W. Paxton

4

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

author name string

Zhou SF

1

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

Kestell P

3

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

language of work or name

0 references

publication date

1 February 2002

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

32

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

87-107

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

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1 reference

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Glucuronidation of diflunisal in liver and kidney microsomes of rat and man.

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Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

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Effect of thalidomide on tumour necrosis factor production and anti-tumour activity induced by 5,6-dimethylxanthenone-4-acetic acid

1 reference

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Metabolism of Arylacetic Acids: 1. The Fate of 1-Naphthylacetic Acid and its Variation with Species and Dose

1 reference

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21 January 2018

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

1 reference

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Studies on the metabolism of arylacetic acids. 6. Comparative metabolic conjugation of 1- and 2-naphthylacetic acids in the guinea pig, mouse, hamster and gerbil

1 reference

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The metabolism of xenobiotics by certain extrahepatic organs and its relation to toxicity

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Selective inhibitors of cytochromes P450.

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Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

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Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

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Extrahepatic metabolism of drugs in humans

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Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs

1 reference

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21 January 2018

Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen

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Allometric issues in drug development

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Dosage regimen design for pharmaceutical studies conducted in animals.

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P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer

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The allometric approach for interspecies scaling of pharmacokinetics and toxicity of anti-cancer drugs

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Potential antitumor agents. 58. Synthesis and structure-activity relationships of substituted xanthenone-4-acetic acids active against the colon 38 tumor in vivo

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A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

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Clearance concepts in pharmacokinetics

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Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.

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Measurement of protein using bicinchoninic acid

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Bosentan, a new endothelin receptor antagonist: prediction of the systemic plasma clearance in man from combined in vivo and in vitro data

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21 January 2018

Commentary: a physiological approach to hepatic drug clearance

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21 January 2018

Drugs and the liver. Part III: Ageing of the liver and the metabolism of drugs

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Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

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21 January 2018

In vitro and in vivo kinetic interactions of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid with thalidomide and diclofenac

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21 January 2018

Reversible binding of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid to plasma proteins and its distribution into blood cells in various species

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21 January 2018

The structure and function of the UDP-glucuronosyltransferase gene family

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The effect of various potential inhibitors, activators and inducers on theN-oxidation of 3-substituted pyridinesin vitro

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21 January 2018

Plasma disposition, metabolism and excretion of the experimental antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit

1 reference

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21 January 2018

Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential

1 reference

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21 January 2018

Light-induced breakdown of flavone acetic acid and xanthenone analogues in solution

1 reference

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21 January 2018

Determination of two major metabolites of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid in hepatic microsomal incubations by high-performance liquid chromatography with fluorescence detection

1 reference

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21 January 2018

Identifiers

10.1080/00498250110092423

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 November 2017

ResearchGate publication ID

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