(Q43900453)

English

Conformational flexibility of the ErbB2 ectodomain and trastuzumab antibody complex as revealed by molecular dynamics and principal component analysis.

scientific article published on 17 November 2012

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Conformational flexibility of the ErbB2 ectodomain and trastuzumab antibody complex as revealed by molecular dynamics and principal component analysis (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

principal component analysis

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1 reference

based on heuristic

inferred from title

Juan F Franco-Gonzalez

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

3

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Javier Martínez-Salazar

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

author name string

Victor L Cruz

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

publication date

17 November 2012

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Europe PubMed Central

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18 February 2020

Journal of Molecular Modeling

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

19

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Europe PubMed Central

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18 February 2020

3

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1227-1236

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

https://scigraph.springernature.com/pub.10.1007/s00894-012-1661-3

0 references

Untangling the ErbB signalling network

1 reference

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21 January 2018

The epidermal growth factor receptor family: biology driving targeted therapeutics

1 reference

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21 January 2018

The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

1 reference

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21 January 2018

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

1 reference

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21 January 2018

Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains

1 reference

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21 January 2018

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization

1 reference

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21 January 2018

Structure of the extracellular region of HER3 reveals an interdomain tether

1 reference

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21 January 2018

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

1 reference

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21 January 2018

Structural Evidence for Loose Linkage between Ligand Binding and Kinase Activation in the Epidermal Growth Factor Receptor

1 reference

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21 January 2018

The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand

1 reference

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21 January 2018

Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.

1 reference

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21 January 2018

An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors

1 reference

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21 January 2018

ERBB receptors and cancer: the complexity of targeted inhibitors

1 reference

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21 January 2018

Size and conformational features of ErbB2 and ErbB3 receptors: a TEM and DLS comparative study

1 reference

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21 January 2018

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

1 reference

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21 January 2018

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

1 reference

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21 January 2018

Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

1 reference

https://api.crossref.org/works/10.1007%2FS00894-012-1661-3

21 January 2018

Study of inhibition effect of herceptin on interaction between heregulin and erbB receptors HER3/HER2 by single-molecule force spectroscopy

1 reference

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21 January 2018

Transmembrane peptides from tyrosine kinase receptor. Mutation-related behavior in a lipid bilayer investigated by molecular dynamics simulations.

1 reference

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21 January 2018

Molecular dynamics simulations of the transmembrane domain of the oncogenic ErbB2 receptor dimer in a DMPC bilayer.

1 reference

https://api.crossref.org/works/10.1007%2FS00894-012-1661-3

21 January 2018

Spatial structure of the dimeric transmembrane domain of the growth factor receptor ErbB2 presumably corresponding to the receptor active state

1 reference

https://api.crossref.org/works/10.1007%2FS00894-012-1661-3

21 January 2018

Atomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study

1 reference

https://api.crossref.org/works/10.1007%2FS00894-012-1661-3

21 January 2018

Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases

1 reference

https://api.crossref.org/works/10.1007%2FS00894-012-1661-3

21 January 2018

A multiscale modeling approach to investigate molecular mechanisms of pseudokinase activation and drug resistance in the HER3/ErbB3 receptor tyrosine kinase signaling network

1 reference

https://api.crossref.org/works/10.1007%2FS00894-012-1661-3

21 January 2018

Structural analysis of the epitopes on erbB2 interacted with inhibitory or non-inhibitory monoclonal antibodies.

1 reference

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21 January 2018

In vivo identification of the interaction site of ErbB2 extracellular domain with its autoinhibitor.

1 reference

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21 January 2018

Synergy between trastuzumab and pertuzumab for human epidermal growth factor 2 (Her2) from colocalization: an in silico based mechanism

1 reference

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21 January 2018

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

1 reference

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21 January 2018

The OPLS [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin

1 reference

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21 January 2018

Potential energy functions for atomic-level simulations of water and organic and biomolecular systems

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21 January 2018

VMD: visual molecular dynamics

1 reference

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21 January 2018

Essential dynamics of proteins

1 reference

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21 January 2018

An efficient method for sampling the essential subspace of proteins.

1 reference

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21 January 2018

Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

1 reference

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21 January 2018

Molecular dynamics of apo-adenylate kinase: a principal component analysis

1 reference

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21 January 2018

SPACE: a suite of tools for protein structure prediction and analysis based on complementarity and environment.

1 reference

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21 January 2018

Differential binding of human immunoagents and Herceptin to the ErbB2 receptor

1 reference

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21 January 2018

High affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticity

1 reference

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21 January 2018

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

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Fluctuation and Cross-correlation Analysis of Protein Motions Observed in Nanosecond Molecular Dynamics Simulations

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Molecular dynamics with coupling to an external bath

1 reference

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21 January 2018

Correlated motions and propagation of the effect of a local conformational change in the transmembrane helix of the c-erb B2 encoded protein and its V659E mutant, studied by molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23160933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through molecular dynamics search

1 reference

https://pubmed.ncbi.nlm.nih.gov/23160933

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detailed description of an alpha helix-->pi bulge transition detected by molecular dynamics simulations of the p185c-erbB2 V659G transmembrane domain

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00894-012-1661-3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23160933%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

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