(Q43913993)

28 November 2017

title

Intracellular pathways of pancreatic β-cell apoptosis in type 1 diabetes (English)

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28 November 2017

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Helen E Thomas

1

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28 November 2017

Thomas W Kay

series ordinal

2

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28 November 2017

publication date

1 November 2011

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Diabetes - Metabolism: Research and Reviews

28 November 2017

published in

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28 November 2017

volume

27

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28 November 2017

issue

8

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28 November 2017

page(s)

790-796

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Beta cell apoptosis in T cell-mediated autoimmune diabetes

28 November 2017

cites work

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21 January 2018

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Apoptosis: Stabbed in the BAX.

21 January 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

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A central role for Bid in granzyme B-induced apoptosis

21 January 2018

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Two CD95 (APO-1/Fas) signaling pathways

21 January 2018

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The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

21 January 2018

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ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

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Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim

21 January 2018

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Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

21 January 2018

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Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

21 January 2018

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Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

21 January 2018

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Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

21 January 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

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Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

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Puma is a dominant regulator of oxidative stress induced Bax activation and neuronal apoptosis.

21 January 2018

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Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

21 January 2018

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Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

21 January 2018

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Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice

21 January 2018

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CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

21 January 2018

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Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice

21 January 2018

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A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death

21 January 2018

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Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.

21 January 2018

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Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.

21 January 2018

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Human and murine granzyme B exhibit divergent substrate preferences

21 January 2018

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The major human and mouse granzymes are structurally and functionally divergent

21 January 2018

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Beta cell MHC class I is a late requirement for diabetes

21 January 2018

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Beta cell apoptosis in diabetes

21 January 2018

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Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

21 January 2018

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Mechanisms of beta cell death in diabetes: a minor role for CD95.

21 January 2018

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Perforin-independent beta-cell destruction by diabetogenic CD8(+) T lymphocytes in transgenic nonobese diabetic mice

21 January 2018

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Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in nonobese diabetic mice.

21 January 2018

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Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci.

21 January 2018

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Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.

21 January 2018

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Effective destruction of Fas-deficient insulin-producing beta cells in type 1 diabetes

21 January 2018

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Contribution of Fas to diabetes development

21 January 2018

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Proapoptotic BH3-only protein Bid is essential for death receptor-induced apoptosis of pancreatic beta-cells.

21 January 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

21 January 2018

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Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.

21 January 2018

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The role for endoplasmic reticulum stress in diabetes mellitus

21 January 2018

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

21 January 2018

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Ablation of C/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice

21 January 2018

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Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

21 January 2018

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A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity

21 January 2018

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Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes.

21 January 2018

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

21 January 2018

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Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis

21 January 2018

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Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

21 January 2018

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Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations.

21 January 2018

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High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat pancreatic islets without activating NFkappaB.

21 January 2018

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Is there a role for locally produced interleukin-1 in the deleterious effects of high glucose or the type 2 diabetes milieu to human pancreatic islets?

21 January 2018

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The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

21 January 2018

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Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL

21 January 2018

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Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

21 January 2018

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Apoptosis and beta-cell destruction in pancreatic islets of NOD mice with spontaneous and cyclophosphamide-accelerated diabetes

21 January 2018

1 reference

7 January 2021

Rapid hybridoma screening method for the identification of monoclonal antibodies to low-abundance cytoplasmic proteins

1 reference

7 January 2021

Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions

1 reference

7 January 2021

The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus

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7 January 2021

Following a diabetogenic T cell from genesis through pathogenesis

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7 January 2021

The role of Fas in autoimmune diabetes

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7 January 2021

Inhibition of autoimmune diabetes by Fas ligand: the paradox is solved

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7 January 2021

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity

1 reference

7 January 2021

Identifiers

DOI

10.1002/DMRR.1253

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28 November 2017

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