(Q43965056)

28 November 2017

title

Interleukin-6 trans-signaling and colonic cancer associated with inflammatory bowel disease (English)

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inflammatory bowel diseases

28 November 2017

main subject

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3

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28 November 2017

2

Dirk Schmidt-Arras

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Stefan Rose-John

object named as

Stefan Rose-John

series ordinal

4

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author name string

Athena Chalaris

series ordinal

1

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28 November 2017

publication date

24 October 2012

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28 November 2017

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28 November 2017

volume

30

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28 November 2017

issue

5

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28 November 2017

page(s)

492-499

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Gp130 and the interleukin-6 family of cytokines

28 November 2017

cites work

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Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling

21 January 2018

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Principles of interleukin (IL)-6-type cytokine signalling and its regulation

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Plasticity and cross-talk of interleukin 6-type cytokines

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Averting inflammation by targeting the cytokine environment

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Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

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Interleukin-6-deficient mice develop mature-onset obesity

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Sympathetic neurons can produce and respond to interleukin 6

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The pro- and anti-inflammatory properties of the cytokine interleukin-6.

21 January 2018

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Hitting a complex target: an update on interleukin-6 trans-signalling

21 January 2018

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Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex

21 January 2018

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Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment.

21 January 2018

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Transgenic blockade of interleukin 6 transsignaling abrogates inflammation

21 January 2018

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IL6 signalling through IL6 receptor and receptor-associated signal transducer, gp130

21 January 2018

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Analysis of interleukin 6 receptor and gp130 expressions and proliferative capability of human CD34+ cells

21 January 2018

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Soluble cytokine receptors are present in normal human urine

21 January 2018

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A possible role for soluble IL-6 receptor in the pathogenesis of systemic onset juvenile chronic arthritis

21 January 2018

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Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress

21 January 2018

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Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.

21 January 2018

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Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor

21 January 2018

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Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing

21 January 2018

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The soluble interleukin-6 receptor is generated by shedding

21 January 2018

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Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

21 January 2018

1 reference

The ADAMs family of metalloproteases: multidomain proteins with multiple functions

21 January 2018

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

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Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

21 January 2018

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ADAM17: a molecular switch to control inflammation and tissue regeneration

21 January 2018

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C-reactive protein: a physiological activator of interleukin 6 receptor shedding.

21 January 2018

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Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide.

21 January 2018

1 reference

21 January 2018

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Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding

21 January 2018

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Identification of ARTS-1 as a novel TNFR1-binding protein that promotes TNFR1 ectodomain shedding

21 January 2018

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An Aminopeptidase, ARTS-1, Is Required for Interleukin-6 Receptor Shedding

21 January 2018

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Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

21 January 2018

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Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

21 January 2018

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STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice

21 January 2018

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TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.

21 January 2018

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Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model

21 January 2018

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

21 January 2018

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gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis.

21 January 2018

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Tumor development in murine ulcerative colitis depends on MyD88 signaling of colonic F4/80+CD11b(high)Gr1(low) macrophages

21 January 2018

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Impaired immune and acute-phase responses in interleukin-6-deficient mice.

21 January 2018

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IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer

21 January 2018

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Stat proteins and oncogenesis

21 January 2018

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Inflammation and cancer: IL-6 and STAT3 complete the link.

21 January 2018

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Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours

21 January 2018

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Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine-independent growth, and blockade of differentiation of embryonic stem cells

21 January 2018

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Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth

21 January 2018

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Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas

21 January 2018

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IL-6: regulator of Treg/Th17 balance

21 January 2018

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Distinct contribution of IL-6, TNF-alpha, IL-1, and IL-10 to T cell-mediated spontaneous autoimmune arthritis in mice

21 January 2018

1 reference

Therapeutic blockade of interleukin-6 in chronic inflammatory disease

21 January 2018

1 reference

Therapeutic targeting of the interleukin-6 receptor.

21 January 2018

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Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease

21 January 2018

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The soluble Interleukin 6 receptor: generation and role in inflammation and cancer

21 January 2018

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Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

21 January 2018

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Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model*

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000341698

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28 November 2017

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