(Q44009139)

English

Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding.

scientific article published in May 2002

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Mutational analysis of Plasmodium falciparum dihydrofolate reductase: the role of aspartate 54 and phenylalanine 223 on catalytic activity and antifolate binding (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Plasmodium falciparum

1 reference

based on heuristic

inferred from title

mutational analysis

1 reference

based on heuristic

inferred from title

Giulio Rastelli

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Yongyuth Yuthavong

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Sumalee Kamchonwongpaisan

6

object named as

Sumalee Kamchonwongpaisan

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

author name string

Worachart Sirawaraporn

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Rachada Sirawaraporn

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Suganya Yongkiettrakul

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Amornpol Anuwatwora

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

publication date

1 May 2002

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Molecular and Biochemical Parasitology

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

121

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

185-193

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Dihydrofolate reductase and antifolate resistance in malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

PS-15: a potent, orally active antimalarial from a new class of folic acid antagonists.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A search for sources of drug resistance by the 4D-QSAR analysis of a set of antimalarial dihydrofolate reductase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structures of Escherichia coli dihydrofolate reductase: the NADP+ holoenzyme and the folate.NADP+ ternary complex. Substrate binding and a model for the transition state

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional role of aspartic acid-27 in dihydrofolate reductase revealed by mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

13C and 15N nuclear magnetic resonance evidence that the active site carboxyl group of dihydrofolate reductase is not involved in the relay of a proton to substrate

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of human dihydrofolate reductase complexed with folate

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Hydrophobic interactions via mutants of Escherichia coli dihydrofolate reductase: separation of binding and catalysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Directed mutagenesis of dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

How do mutations at phenylalanine-153 and isoleucine-155 partially suppress the effects of the aspartate-27-->serine mutation in Escherichia coli dihydrofolate reductase?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dihydrofolate reductase mutations and chromosomal changes associated with pyrimethamine resistance of Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Dihydrofolate reductase from Escherichia coli: probing the role of aspartate-27 and phenylalanine-137 in enzyme conformation and the binding of NADPH

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

A second-site mutation at phenylalanine-137 that increases catalytic efficiency in the mutant aspartate-27----serine Escherichia coli dihydrofolate reductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900035-X

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0166-6851(02)00035-X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12034452%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q44009139&oldid=2105603673"