(Q44025824)

29 November 2017

title

Constitutional epimutation as a mechanism for cancer causality and heritability? (English)

1 reference

29 November 2017

1 reference

Megan P Hitchins

1

1 reference

29 November 2017

language of work or name

English

0 references

publication date

18 September 2015

1 reference

29 November 2017

published in

Nature Reviews Cancer

1 reference

29 November 2017

volume

15

1 reference

29 November 2017

issue

10

1 reference

29 November 2017

page(s)

625-634

1 reference

Missing heritability and strategies for finding the underlying causes of complex disease

29 November 2017

cites work

1 reference

Personal genomes: The case of the missing heritability

21 January 2018

1 reference

Epigenetics as a unifying principle in the aetiology of complex traits and diseases.

21 January 2018

1 reference

Genome-wide association studies: potential next steps on a genetic journey

21 January 2018

1 reference

Worms gang up on bacteria

21 January 2018

1 reference

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

21 January 2018

1 reference

The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

21 January 2018

1 reference

Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma

21 January 2018

1 reference

The 5-methylcytosine content of DNA from human tumors

21 January 2018

1 reference

Increased methylation variation in epigenetic domains across cancer types

21 January 2018

1 reference

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

21 January 2018

1 reference

Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers.

21 January 2018

1 reference

CpG island methylator phenotype in colorectal cancer

21 January 2018

1 reference

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

21 January 2018

1 reference

Genome-scale analysis of aberrant DNA methylation in colorectal cancer

21 January 2018

1 reference

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

The role of mutations in epigenetic regulators in myeloid malignancies

21 January 2018

1 reference

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis

21 January 2018

1 reference

The CIMP Phenotype in BRAF Mutant Serrated Polyps from a Prospective Colonoscopy Patient Cohort

21 January 2018

1 reference

MGMT methylation is associated primarily with the germline C>T SNP (rs16906252) in colorectal cancer and normal colonic mucosa

21 January 2018

1 reference

Methylation of the 3p22 region encompassing MLH1 is representative of the CpG island methylator phenotype in colorectal cancer.

21 January 2018

1 reference

Genomic hypomethylation and CpG island hypermethylation in prostatic intraepithelial neoplasm

21 January 2018

1 reference

Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer

21 January 2018

1 reference

Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study

21 January 2018

1 reference

Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin

21 January 2018

1 reference

Detection of MGMT promoter methylation in normal individuals is strongly associated with the T allele of the rs16906252 MGMT promoter single nucleotide polymorphism.

21 January 2018

1 reference

21 January 2018

1 reference

Intra-individual change over time in DNA methylation with familial clustering

21 January 2018

1 reference

Integrative eQTL-based analyses reveal the biology of breast cancer risk loci

21 January 2018

1 reference

Is there a link between genome-wide hypomethylation in blood and cancer risk?

21 January 2018

1 reference

Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer risk

21 January 2018

1 reference

Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women

21 January 2018

1 reference

The inheritance of epigenetic defects

21 January 2018

1 reference

Constitutional (germline) MLH1 epimutation as an aetiological mechanism for hereditary non-polyposis colorectal cancer

21 January 2018

1 reference

Hypomethylation of D4Z4 in 4q-linked and non-4q-linked facioscapulohumeral muscular dystrophy

21 January 2018

1 reference

Epimutations and cancer predisposition: importance and mechanisms

21 January 2018

1 reference

Genomic imprinting and Wilms' tumor

21 January 2018

1 reference

Epigenotype-phenotype correlations in Beckwith-Wiedemann syndrome

21 January 2018

1 reference

Epigenetic alterations of H19 and LIT1 distinguish patients with Beckwith-Wiedemann syndrome with cancer and birth defects

21 January 2018

1 reference

Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor.

21 January 2018

1 reference

Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer.

21 January 2018

1 reference

Milestones of Lynch syndrome: 1895-2015.

21 January 2018

1 reference

Extensive but hemiallelic methylation of the hMLH1 promoter region in early-onset sporadic colon cancers with microsatellite instability

21 January 2018

1 reference

Germline epimutation of MLH1 in individuals with multiple cancers

21 January 2018

1 reference

MLH1 Germline Epimutations as a Factor in Hereditary Nonpolyposis Colorectal Cancer

21 January 2018

1 reference

Inheritance of a Cancer-AssociatedMLH1Germ-Line Epimutation

21 January 2018

1 reference

The role of epigenetics in Lynch syndrome

21 January 2018

1 reference

De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one

21 January 2018

1 reference

MLH1 methylation screening is effective in identifying epimutation carriers

21 January 2018

1 reference

Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

21 January 2018

1 reference

Allele-specific CDH1 downregulation and hereditary diffuse gastric cancer

21 January 2018

1 reference

BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with a BRCA1 tumour phenotype

21 January 2018

1 reference

Constitutive promoter methylation of BRCA1 and RAD51C in patients with familial ovarian cancer and early-onset sporadic breast cancer

21 January 2018

1 reference

Monozygotic twins discordant for constitutive BRCA1 promoter methylation, childhood cancer and secondary cancer

21 January 2018

1 reference

Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer

21 January 2018

1 reference

No difference in the frequency of locus-specific methylation in the peripheral blood DNA of women diagnosed with breast cancer and age-matched controls.

21 January 2018

1 reference

Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome

21 January 2018

1 reference

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

21 January 2018

1 reference

Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1.

21 January 2018

1 reference

Recurrence and variability of germline EPCAM deletions in Lynch syndrome.

21 January 2018

1 reference

Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study

21 January 2018

1 reference

Lynch syndrome-associated extracolonic tumors are rare in two extended families with the same EPCAM deletion

21 January 2018

1 reference

Dominantly Inherited Constitutional Epigenetic Silencing of MLH1 in a Cancer-Affected Family Is Linked to a Single Nucleotide Variant within the 5′UTR

21 January 2018

1 reference

The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype

21 January 2018

1 reference

Biallelic MLH1 SNP cDNA expression or constitutional promoter methylation can hide genomic rearrangements causing Lynch syndrome

21 January 2018

1 reference

Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia

21 January 2018

1 reference

Germline epimutations of APC are not associated with inherited colorectal polyposis

21 January 2018

1 reference

Constitutional promoter methylation and risk of familial melanoma

21 January 2018

1 reference

An epigenetic mutation responsible for natural variation in floral symmetry

21 January 2018

1 reference

A naturally occurring epigenetic mutation in a gene encoding an SBP-box transcription factor inhibits tomato fruit ripening.

21 January 2018

1 reference

Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery

21 January 2018

1 reference

Epigenetic inheritance at the agouti locus in the mouse

21 January 2018

1 reference

Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission

21 January 2018

1 reference

Epigenetic reprogramming in plant and animal development

21 January 2018

1 reference

Persistent epigenetic differences associated with prenatal exposure to famine in humans

21 January 2018

1 reference

Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19

21 January 2018

1 reference

Dioxin (TCDD) induces epigenetic transgenerational inheritance of adult onset disease and sperm epimutations

21 January 2018

1 reference

Pesticide methoxychlor promotes the epigenetic transgenerational inheritance of adult-onset disease through the female germline

21 January 2018

1 reference

Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming

21 January 2018

1 reference

Longevity determined by paternal ancestors' nutrition during their slow growth period

21 January 2018

1 reference

Cardiovascular and diabetes mortality determined by nutrition during parents' and grandparents' slow growth period

21 January 2018

1 reference

Transgenerational response to nutrition, early life circumstances and longevity.

21 January 2018

1 reference

Transgenerational epigenetic inheritance: how important is it?

21 January 2018

1 reference

Erasure of MLH1 methylation in spermatozoa—implications for epigenetic inheritance

21 January 2018

1 reference

Epigenetic inheritance and the missing heritability problem

21 January 2018

1 reference

Environment-sensitive epigenetics and the heritability of complex diseases

21 January 2018

1 reference

DNA methylation contributes to natural human variation

21 January 2018

1 reference

Dynamic CpG island methylation landscape in oocytes and preimplantation embryos

21 January 2018

1 reference

Dynamic reprogramming of DNA methylation in the early mouse embryo.

21 January 2018

1 reference

Linkage of DNA Methylation Quantitative Trait Loci to Human Cancer Risk

21 January 2018

1 reference

Molecular subtypes and phenotypic expression of Beckwith–Wiedemann syndrome

21 January 2018

1 reference

Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour

21 January 2018

1 reference

Absence of Germline Epimutation of the CDKN2A Gene in Familial Melanoma

21 January 2018

1 reference

The fundamental role of epigenetic events in cancer

21 January 2018

1 reference

Hypomethylation of ras oncogenes in primary human cancers

31 March 2020

1 reference

Chromosomal Instability and Tumors Promoted by DNA Hypomethylation

31 March 2020

1 reference

Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour

31 March 2020

1 reference

Hypomethylation of DNA from benign and malignant human colon neoplasms

31 March 2020

1 reference

Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability

31 March 2020

1 reference

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk

31 March 2020

1 reference

31 March 2020

1 reference

The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide

31 March 2020

1 reference

On the meaning of the word 'epimutation'

31 March 2020

1 reference

Epigenetic lesions at the H19 locus in Wilms' tumour patients

31 March 2020

1 reference

Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor

31 March 2020

1 reference

Dawning of the epigenetic era in hereditary cancer

31 March 2020

1 reference

Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies

31 March 2020

1 reference

Endocrine disrupters: the new players able to affect the epigenome

31 March 2020

1 reference

Multigenerational and transgenerational effects of endocrine disrupting chemicals: A role for altered epigenetic regulation?

31 March 2020

1 reference

Transgenerational effects of betel-quid chewing on the development of the metabolic syndrome in the Keelung Community-based Integrated Screening Program

31 March 2020

1 reference

Epigenetic variation illustrated by DNA methylation patterns of the fragile-X gene FMR1

31 March 2020

1 reference

Epimutations in human disease.

31 March 2020

1 reference

12 December 2020

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability

1 reference

12 December 2020

A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor

1 reference

12 December 2020

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines

1 reference

12 December 2020

Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing

1 reference

12 December 2020

Chromatin signature of widespread monoallelic expression

1 reference

12 December 2020

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC4001

1 reference

29 November 2017

1 reference