(Q44060421)

29 November 2017

title

Mutagenicity of gamma-radiation, mitomycin C, and etoposide in the Hprt and Tk genes of Tk(+/-) mice (English)

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29 November 2017

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Vasily N Dobrovolsky

1

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29 November 2017

Joseph G Shaddock

series ordinal

2

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29 November 2017

Robert H Heflich

series ordinal

3

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29 November 2017

publication date

1 January 2002

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Environmental and Molecular Mutagenesis

29 November 2017

published in

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29 November 2017

volume

39

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29 November 2017

issue

4

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29 November 2017

page(s)

342-347

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Mutagenicity testing in mammalian cells. I. Derivation of a Chinese hamster ovary cell line heterozygous for the adenine phosphoribosyltransferase and thymidine kinase loci

29 November 2017

cites work

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Development and utilization of the rat lymphocyte hprt mutation assay

21 January 2018

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T-cell cloning to detect the mutant 6-thioguanine-resistant lymphocytes present in human peripheral blood

21 January 2018

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Potent clastogenicity of the human carcinogen etoposide to the mouse bone marrow and mouse lymphoma L5178Y cells: comparison to Salmonella responses.

21 January 2018

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Role of the human RAD51 protein in homologous recombination and double-stranded-break repair

21 January 2018

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Isolation and structure of an intrastrand cross-link adduct of mitomycin C and DNA

21 January 2018

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A mutational assay system using the thymidine kinase locus in mouse lymphoma cells

21 January 2018

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Nature of mutation in the human hprt gene following in vivo exposure to ionizing radiation of cesium-137.

21 January 2018

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Development of a novel mouse tk+/- embryonic stem cell line for use in mutagenicity studies

21 January 2018

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Tk+/- mouse model for detecting in vivo mutation in an endogenous, autosomal gene

21 January 2018

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7,12-dimethylbenz[a]anthracene-induced mutation in the Tk gene of Tk(+/-) mice: automated scoring of lymphocyte clones using a fluorescent viability indicator.

21 January 2018

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LacZ transgenic mouse models: their application in genetic toxicology

21 January 2018

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Partners and pathwaysrepairing a double-strand break.

21 January 2018

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Etoposide: four decades of development of a topoisomerase II inhibitor

21 January 2018

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Comparative induction of micronuclei in repair-deficient and -proficient Chinese hamster cell lines following clastogen or aneugen exposures

21 January 2018

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A method to quantify spontaneous and in vivo induced thioguanine-resistant mouse lymphocytes

21 January 2018

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Molecular mechanisms of DNA double strand break repair

21 January 2018

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Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice

21 January 2018

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Genetic instabilities in human cancers

21 January 2018

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Isolation of an APRT heterozygote from TK6 human lymphoblasts: predominance of multi-locus loss of heterozygosity among spontaneous APRT-mutants

21 January 2018

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Multiple genetic alterations in human carcinogenesis

21 January 2018

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Transgenic and gene knockout mice in cancer research

21 January 2018

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Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse

21 January 2018

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Loss of heterozygosity in somatic cells of the mouse. An important step in cancer initiation?

21 January 2018

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Oral etoposide in lymphoma

21 January 2018

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Extended-schedule oral etoposide in selected neoplasms and overview of administration and scheduling issues

21 January 2018

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Role of radioadaptation on radiation-induced thymic lymphoma in mice

21 January 2018

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Genotoxicity of several clinically used topoisomerase II inhibitors

21 January 2018

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Identification and chromosomal assignment of two heterozygous mutations in the Trp53 gene in L5178Y/Tk(+/-)-3.7.2C mouse lymphoma cells

21 January 2018

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Molecular analysis of in vivo mutations induced by N-ethyl-N-nitrosourea in the autosomal Tk and the X-linked Hprt genes of mouse lymphocytes

21 January 2018

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Repair processes in radiation biology.

21 January 2018

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Quantitative and qualitative effect of gamma-ray dose-rate on mutagenesis in human lymphoblastoid cells

21 January 2018

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The in vivo rat micronucleus test: integration with a 14-day study

21 January 2018

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Induction of micronuclei in human, goat, rabbit peripheral blood lymphocytes and mouse splenic lymphocytes irradiated in vitro with gamma radiation

21 January 2018

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Generation of mutant mice with large chromosomal deletion by use of irradiated ES cells--analysis of large deletion around hprt locus of ES cell

21 January 2018

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Noncovalent binding of a mitomycin C metabolite, 2,7-diaminomitosene, to duplex DNA

21 January 2018

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Germ-cell mutagenicity of etoposide: induction of meiotic micronuclei in cultured rat seminiferous tubules

21 January 2018

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The concomitant detection of gene mutation and micronucleus induction by mitomycin C in vivo using lacZ transgenic mice

21 January 2018

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Inversion due to intrachromosomal recombination produced by carcinogens in a transgenic mouse model

21 January 2018

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Mechanism of monofunctional and bifunctional alkylation of DNA by mitomycin C

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/EM.10074

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29 November 2017

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