(Q44172611)

English

Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells

scientific article published on 3 May 2010

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

Oncogenic E17K mutation in the pleckstrin homology domain of AKT1 promotes v-Abl-mediated pre-B-cell transformation and survival of Pim-deficient cells (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

author name string

G Guo

1

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

X Qiu

2

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

S Wang

3

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

Y Chen

4

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

P B Rothman

5

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

Z Wang

6

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

Y Chen

7

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

G Wang

8

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

J-L Chen

9

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

language of work or name

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publication date

3 May 2010

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Europe PubMed Central

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30 November 2017

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Europe PubMed Central

PubMed publication ID

30 November 2017

29

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PubMed publication ID

30 November 2017

26

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PubMed publication ID

30 November 2017

3845-3853

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

https://scigraph.springernature.com/pub.10.1038/onc.2010.149

0 references

The survival kinases Akt and Pim as potential pharmacological targets

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

AKT1 mutations in bladder cancer: identification of a novel oncogenic mutation that can co-operate with E17K.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

The serine/threonine kinase Pim-1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

AKT1(E17K) in human solid tumours

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

A new mutational AKTivation in the PI3K pathway

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Coatomer-bound Cdc42 regulates dynein recruitment to COPI vesicles

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

JAK-STAT signaling activated by Abl oncogenes

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Delineation of prognostic biomarkers in prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Mutations in the catalytic subunit of class IA PI3K confer leukemogenic potential to hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

ABL oncogenes and phosphoinositide 3-kinase: mechanism of activation and downstream effectors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

AKT1 (E17K) mutation in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Pim-1 regulates cardiomyocyte survival downstream of Akt.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Functional involvement of Akt signaling downstream of Jak1 in v-Abl-induced activation of hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Analysis of oncogenic AKT1 p.E17K mutation in carcinomas of the biliary tract and liver

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

BCR-ABL oncogenic transformation of NIH 3T3 fibroblasts requires the IL-3 receptor

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Inhibition of vimentin or beta1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

AKT1 E17 K pleckstrin homology domain mutation in urothelial carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

21 January 2018

Chronic lymphocytic leukaemia and acute myeloid leukaemia are not associated with AKT1 pleckstrin homology domain (E17K) mutations

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

31 March 2020

PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.149

31 March 2020

Identifiers

10.1038/ONC.2010.149

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 November 2017

ResearchGate publication ID

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