(Q44186888)

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Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease

scientific article published on 12 April 2014

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Europe PubMed Central

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30 November 2017

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease (English)

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Europe PubMed Central

PubMed publication ID

30 November 2017

Huntington's disease

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inferred from title

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24728190%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

Penelope J. Hallett

7

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13 June 2020

6

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13 June 2020

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Emily M Rocha

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13 June 2020

Jesse R McLean

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13 June 2020

Melissa A Hayes

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13 June 2020

Sarah C Izen

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13 June 2020

publication date

12 April 2014

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30 November 2017

Human Molecular Genetics

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13 June 2020

23

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13 June 2020

17

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13 June 2020

4510-4527

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13 June 2020

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Light and electron microscopic characterization of the evolution of cellular pathology in HdhQ92 Huntington's disease knock-in mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Light and electron microscopic characterization of the evolution of cellular pathology in the Hdh(CAG)150 Huntington's disease knock-in mouse.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV alpha-synucleinopathy.

1 reference

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21 January 2018

Pyramidal cell loss in motor cortices in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Regional and progressive thinning of the cortical ribbon in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Axonal transport of N-terminal huntingtin suggests early pathology of corticostriatal projections in Huntington disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Huntington disease and the huntingtin protein

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Cortical and brainstem LTP-like plasticity in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Generalized brain and skin proteasome inhibition in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Brain-derived neurotrophic factor in patients with Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Axonal transport deficits and neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Fast transport and retrograde movement of huntingtin and HAP 1 in axons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Role of brain-derived neurotrophic factor in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Mutant Huntingtin alters retrograde transport of TrkB receptors in striatal dendrites.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Induced pluripotent stem cells from patients with Huntington's disease show CAG-repeat-expansion-associated phenotypes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Rab GTPases, membrane trafficking and diseases

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Altered distribution of striatal activity-dependent synaptic plasticity in the 3-nitropropionic acid model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

A similar impairment in CA3 mossy fibre LTP in the R6/2 mouse model of Huntington's disease and in the complexin II knockout mouse

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Dopamine-dependent long term potentiation in the dorsal striatum is reduced in the R6/2 mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Light and electron microscopic characterization of the evolution of cellular pathology in the R6/1 Huntington's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Light and electron microscopic characterization of the evolution of cellular pathology in YAC128 Huntington's disease transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Characterization of a rat model of Huntington's disease based on targeted expression of mutant huntingtin in the forebrain using adeno-associated viral vectors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Alleviation of motor hyperactivity and neurochemical deficits by endocannabinoid uptake inhibition in a rat model of Huntington's disease.

1 reference

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21 January 2018

Genetics and neuropathology of Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Morphometric analysis of the prefrontal cortex in Huntington's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Apoptosis of retrogradely degenerating neurons occurs in association with the accumulation of perikaryal mitochondria and oxidative damage to the nucleus

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

1 reference

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21 January 2018

Altered striatal amino acid neurotransmitter release monitored using microdialysis in R6/1 Huntington transgenic mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

The Q175 mouse model of Huntington's disease shows gene dosage- and age-related decline in circadian rhythms of activity and sleep

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Circadian and sleep disorder in Huntington's disease

1 reference

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21 January 2018

Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's Disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

In vivo Dopamine Efflux is Decreased in Striatum of both Fragment (R6/2) and Full-Length (YAC128) Transgenic Mouse Models of Huntington's Disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Nucleocytoplasmic transport

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Huntington's disease: molecular basis of neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

dnc-1/dynactin 1 knockdown disrupts transport of autophagosomes and induces motor neuron degeneration

1 reference

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Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons

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21 January 2018

Cytoplasmic dynein in neurodegeneration

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Huntingtin facilitates dynein/dynactin-mediated vesicle transport.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU166

21 January 2018

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

1 reference

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21 January 2018

Systemic delivery of recombinant brain derived neurotrophic factor (BDNF) in the R6/2 mouse model of Huntington's disease

1 reference

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21 January 2018

Relationship between BDNF expression in major striatal afferents, striatum morphology and motor behavior in the R6/2 mouse model of Huntington's disease.

1 reference

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21 January 2018

Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation

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BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases

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21 January 2018

Dendritic spine instability leads to progressive neocortical spine loss in a mouse model of Huntington's disease.

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21 January 2018

Early changes in Huntington's disease patient brains involve alterations in cytoskeletal and synaptic elements

1 reference

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21 January 2018

Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.

1 reference

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21 January 2018

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus.

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21 January 2018

Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein.

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Loss of normal huntingtin function: new developments in Huntington's disease research

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