(Q44273780)

1 December 2017

title

Influence of mild liver impairment on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist (English)

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1 December 2017

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Paul L M van Giersbergen

1

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1 December 2017

Gabriela Popescu

2

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1 December 2017

Frédéric Bodin

3

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1 December 2017

Jasper Dingemanse

4

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1 December 2017

publication date

1 January 2003

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The Journal of Clinical Pharmacology

1 December 2017

published in

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1 December 2017

volume

43

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1 December 2017

issue

1

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1 December 2017

page(s)

15-22

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Endothelin system: the double-edged sword in health and disease

1 December 2017

cites work

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https://api.crossref.org/works/10.1177%2F0091270002239701

Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270002239701

Bosentan and the endothelin system in congestive heart failure.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270002239701

Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270002239701

Pharmacokinetics and pharmacodynamics of the endothelin-receptor antagonist bosentan in healthy human subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Influence of food intake and formulation on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Pulmonary hypertension associated with liver cirrhosis: an echocardiographic study.

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270002239701

Transection of the oesophagus for bleeding oesophageal varices

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270002239701

Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270002239701

Pharmacokinetics of valsartan in patients with liver disease

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270002239701

Cardiovascular drug therapy in patients with hepatic diseases and patients with congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Changes in plasma protein binding have little clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Effects of liver disease on pharmacokinetics. An update

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure

21 January 2018

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https://api.crossref.org/works/10.1177%2F0091270002239701

The endothelin family of peptides: local hormones with diverse roles in health and disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Primary pulmonary hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Multiple-dose pharmacokinetics, safety, and tolerability of bosentan, an endothelin receptor antagonist, in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Influence of severe renal dysfunction on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Bosentan therapy for pulmonary arterial hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Simultaneous determination of bosentan and its three major metabolites in various biological matrices and species using narrow bore liquid chromatography with ion spray tandem mass spectrometric detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F0091270002239701

21 January 2018

Identifiers

DOI

10.1177/0091270002239701

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1 December 2017

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