(Q33789233)

29 July 2017

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title

Effects of liver disease on pharmacokinetics. An update (English)

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29 July 2017

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Rodighiero V

1

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29 July 2017

1 November 1999

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Clinical Pharmacokinetics

29 July 2017

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29 July 2017

37

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29 July 2017

5

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29 July 2017

399-431

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https://scigraph.springernature.com/pub.10.2165/00003088-199937050-00004

29 July 2017

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cites work

Effects of liver diseases on drug metabolism.

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12 December 2020

Multiple-dose pharmacokinetics of pefloxacin in patients with hepatocellular deficiency

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12 December 2020

The effect of hepatic cirrhosis on the pharmacokinetics and blood pressure response to nicardipine

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12 December 2020

Structure-activity and structure-side-effect relationships for the quinolone antibacterials

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12 December 2020

Strategy of FK 506 therapy in liver transplant patients: effect of graft function

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12 December 2020

Clinical pharmacokinetics of tacrolimus

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12 December 2020

Laboratory tests and diagnostic procedures in evaluation of liver disease

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12 December 2020

Biotransformation of caffeine, paraxanthine, theobromine and theophylline by cDNA-expressed human CYP1A2 and CYP2E1

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12 December 2020

Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans

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12 December 2020

Age, disease, and cimetidine disposition in healthy subjects and chronically ill patients

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12 December 2020

Cirrhosis of the liver markedly impairs the elimination of mexiletine

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12 December 2020

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

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12 December 2020

Tropisetron. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential as an antiemetic

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12 December 2020

Nimodipine disposition and haemodynamic effects in patients with cirrhosis and age-matched controls

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12 December 2020

Pharmacokinetics of omeprazole in cirrhotic patients

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12 December 2020

Pharmacokinetics of felodipine in patients with liver disease

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12 December 2020

Correlation of caffeine elimination and Child's classification in liver cirrhosis

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12 December 2020

Is glucuronidation truly preserved in patients with liver disease?

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12 December 2020

Fluvastatin: a review of its pharmacology and use in the management of hypercholesterolaemia

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12 December 2020

Pharmacokinetics of midazolam following intravenous and oral administration in patients with chronic liver disease and in healthy subjects.

1 reference

12 December 2020

Influence of the degree of liver failure on systemic and splanchnic haemodynamics and on response to propranolol in patients with cirrhosis

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12 December 2020

Clinical pharmacokinetics in patients with liver disease

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12 December 2020

Clinical implications of the biopharmaceutical properties of fluvastatin.

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12 December 2020

Bioavailability and elimination of nitrendipine in liver disease

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12 December 2020

Pefloxacin clinical pharmacokinetics

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12 December 2020

Pharmacokinetics of grepafloxacin after oral administration of single and repeat doses in healthy young males

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12 December 2020

Mechanism of the excessive sedative response of cirrhotics to benzodiazepines: model experiments with triazolam.

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12 December 2020

The use of plasma levels for FK 506 dosing in liver-grafted patients

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12 December 2020

Flumazenil disposition and elimination in cirrhosis

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12 December 2020

Influence of hepatic dysfunction on the pharmacokinetics of propafenone.

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12 December 2020

Clinical pharmacokinetics of zidovudine. An update

1 reference

12 December 2020

Nisoldipine: kinetics and effects on blood pressure and heart rate in patients with liver cirrhosis after intravenous and oral administration

1 reference

12 December 2020

Pharmacokinetics and protein binding of cefpiramide in patients with alcoholic cirrhosis

1 reference

12 December 2020

The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver

1 reference

12 December 2020

Clinical pharmacokinetics of ketanserin

1 reference

12 December 2020

Pharmacokinetics of lansoprazole in patients with renal or liver disease of varying severity

1 reference

12 December 2020

Pharmacokinetics of flecainide in patients with cirrhosis of the liver

1 reference

12 December 2020

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

1 reference

12 December 2020

Guide to drug dosage in hepatic disease

1 reference

12 December 2020

Pharmacokinetics of the novel antiestrogenic agent toremifene in subjects with altered liver and kidney function.

1 reference

12 December 2020

Pharmacokinetics and bioavailability of zidovudine and its glucuronidated metabolite in patients with human immunodeficiency virus infection and hepatic disease (AIDS Clinical Trials Group protocol 062).

1 reference

12 December 2020

Comparison of diuretic effects and pharmacokinetics of torasemide and furosemide after a single oral dose in patients with hydropically decompensated cirrhosis of the liver

1 reference

12 December 2020

The effect of age and liver disease on the pharmacokinetics of the calcium antagonist, nisoldipine

1 reference

12 December 2020

Selective effect of liver disease on the activities of specific metabolizing enzymes: investigation of cytochromes P450 2C19 and 2D6.

1 reference

12 December 2020

Pantoprazole. A review of its pharmacological properties and therapeutic use in acid-related disorders

1 reference

12 December 2020

Losartan potassium: a review of its pharmacology, clinical efficacy and tolerability in the management of hypertension

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12 December 2020

Fluoxetine disposition and elimination in cirrhosis

1 reference

12 December 2020

Effect of liver impairment on the pharmacokinetics of tolcapone and its metabolites

1 reference

12 December 2020

Oral flecainide pharmacokinetics in patients with impaired renal function

1 reference

12 December 2020

Flumazenil. A reappraisal of its pharmacological properties and therapeutic efficacy as a benzodiazepine antagonist

1 reference

12 December 2020

Clinical pharmacokinetics of alprazolam. Therapeutic implications

1 reference

12 December 2020

Absorption and disposition of moclobemide in patients with advanced age or reduced liver or kidney function

1 reference

12 December 2020

Pharmacokinetics of fluvoxamine maleate in patients with liver cirrhosis after single-dose oral administration

1 reference

12 December 2020

Pharmacokinetics of ketanserin in patients with cirrhosis

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12 December 2020

Clinical pharmacokinetics of drugs used in the treatment of gastrointestinal diseases (Part I).

1 reference

12 December 2020

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans

1 reference

12 December 2020

Cyclosporin. A review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (Neoral).

1 reference

12 December 2020

Clinical pharmacology of loop diuretics in health and disease

1 reference

12 December 2020

P450 enzymes. Inhibition mechanisms, genetic regulation and effects of liver disease

1 reference

12 December 2020

Differential alterations of cytochrome P450 proteins in livers from patients with severe chronic liver disease

1 reference

12 December 2020

Pharmacokinetics of paroxetine in patients with cirrhosis

1 reference

12 December 2020

Gallopamil. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in ischaemic heart disease

1 reference

12 December 2020

Moclobemide. A review of its pharmacological properties and therapeutic use in depressive illness

1 reference

12 December 2020

Pharmacokinetics of Zidovudine in HIV-Positive Patients with Liver Disease

1 reference

12 December 2020

Pharmacokinetics of metoclopramide in patients with liver cirrhosis.

1 reference

12 December 2020

Contribution of the intestine to the first-pass metabolism of felodipine in the rat

1 reference

12 December 2020

Validation of the five-drug "Pittsburgh cocktail" approach for assessment of selective regulation of drug-metabolizing enzymes

1 reference

12 December 2020

Clinical pharmacokinetics and pharmacodynamics of torasemide

1 reference

12 December 2020

Pravastatin. A reappraisal of its pharmacological properties and clinical effectiveness in the management of coronary heart disease

1 reference

12 December 2020

Absolute bioavailability of metoclopramide given orally or by enema in patients with normal liver function or with cirrhosis of the liver

1 reference

12 December 2020

Pharmacokinetic optimisation of angiotensin converting enzyme (ACE) inhibitor therapy

1 reference

12 December 2020

Effect of hepatic dysfunction and T tube clamping on FK 506 pharmacokinetics and trough concentrations

1 reference

12 December 2020

Pharmacokinetics of ornidazole in patients with acute viral hepatitis, alcoholic cirrhosis, and extrahepatic cholestasis

1 reference

12 December 2020

The pharmacokinetics of caffeine and its dimethylxanthine metabolites in patients with chronic liver disease

1 reference

12 December 2020

Grand mal seizures as a complication of treatment with pefloxacin in patients with cirrhosis. A report of three cases.

1 reference

12 December 2020

Comparison of in vitro and in vivo biotransformation in patients with liver disease of differing severity

1 reference

12 December 2020

Pharmacokinetics of FK506 in liver transplant recipients after continuous intravenous infusion

1 reference

12 December 2020

Pharmacokinetics of enalapril and lisinopril in subjects with normal and impaired hepatic function

1 reference

12 December 2020

Pharmacokinetics of [14C]omeprazole in patients with liver cirrhosis

1 reference

12 December 2020

Tropisetron. A review of the clinical experience

1 reference

12 December 2020

Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis.

1 reference

12 December 2020

Single-dose pharmacokinetics of nefazodone in healthy young and elderly subjects and in subjects with renal or hepatic impairment

1 reference

12 December 2020

Mexiletine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in the treatment of arrhythmias

1 reference

12 December 2020

Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily

1 reference

12 December 2020

Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update

1 reference

12 December 2020

Pharmacokinetics of zidovudine in patients with liver cirrhosis

1 reference

12 December 2020

Pharmacokinetic study of omeprazole in elderly healthy volunteers

1 reference

12 December 2020

Oral pharmacokinetics and ascitic fluid penetration of pefloxacin in cirrhosis

1 reference

12 December 2020

Pharmacokinetics of valsartan in patients with liver disease

1 reference

12 December 2020

Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression

1 reference

12 December 2020

Clinical pharmacokinetics of fluoxetine

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12 December 2020

Clinical pharmacokinetics of calcium antagonists. An update

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12 December 2020

Transection of the oesophagus for bleeding oesophageal varices

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12 December 2020

Pharmacokinetics of various single intravenous and oral doses of omeprazole

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12 December 2020

The pharmacokinetics of intravenous ondansetron in patients with hepatic impairment

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12 December 2020

Pharmacokinetics and safety of tiagabine in subjects with various degrees of hepatic function

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12 December 2020

Single- and multiple-dose pharmacokinetics of nefazodone in patients with hepatic cirrhosis

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12 December 2020

Demographic factors affecting the pharmacokinetics of cyclosporine estimated by radioimmunoassay

1 reference

12 December 2020

Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion

1 reference

12 December 2020

Nighttime dosing of triazolam in patients with liver disease and normal subjects: kinetics and daytime effects.

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12 December 2020

Pharmacokinetics of midazolam in anaesthetized cirrhotic patients.

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12 December 2020

Clinical pharmacokinetics of selective serotonin reuptake inhibitors

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12 December 2020

Intrinsic hepatic clearance and Child-Turcotte classification for assessment of liver function in cirrhosis

1 reference

12 December 2020

Measuring lidocaine metabolite--monoethylglycinexylidide as a quantitative index of hepatic function in adults with chronic hepatitis and cirrhosis.

1 reference

12 December 2020

Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives

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12 December 2020

Caffeine clearance in cirrhosis. The value of simplified determinations of liver metabolic capacity

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12 December 2020

Irbesartan. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in the management of hypertension

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of intravenous midazolam in patients with severe alcoholic cirrhosis

1 reference

12 December 2020

Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients

1 reference

12 December 2020

Alprazolam Pharmacokinetics in Alcoholic Liver Disease

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12 December 2020

Clinical pharmacokinetics of stavudine

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12 December 2020

The anti-secretory effect and pharmacokinetics of omeprazole in chronic liver disease

1 reference

12 December 2020

Pharmacokinetics and safety of a single dose of stavudine (d4T) in patients with severe hepatic impairment.

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12 December 2020

Drug administration in chronic liver disease

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12 December 2020

Bioavailability, pharmacokinetics, and pharmacodynamics of torsemide in patients with cirrhosis

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12 December 2020

Steady-state pharmacokinetics of nitrendipine in hepatic insufficiency

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12 December 2020

Clinical pharmacology of pravastatin, a selective inhibitor of HMG-CoA reductase

1 reference

12 December 2020

Pefloxacin kinetics in cirrhosis

1 reference

12 December 2020

Mephenytoin disposition and serum bile acids as indices of hepatic function in chronic viral hepatitis

1 reference

12 December 2020

A peek at the child-turcotte classification

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12 December 2020

New antiarrhythmic drugs

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12 December 2020

Pharmacokinetics of nifedipine after oral administration in chronic liver disease

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12 December 2020

Overview of the pharmacokinetics of fluvoxamine

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12 December 2020

Propafenone. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in cardiac arrhythmias

1 reference

12 December 2020

CYP3A4 and CYP2A6 activities marked by the metabolism of lignocaine and coumarin in patients with liver and kidney diseases and epileptic patients

1 reference

12 December 2020

Ondansetron clinical pharmacokinetics

1 reference

12 December 2020

The pharmacokinetics of paroxetine in patients with liver cirrhosis

1 reference

12 December 2020

Pharmacokinetics of the newer benzodiazepines

1 reference

12 December 2020

Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders

1 reference

12 December 2020

Toremifene. A review of its pharmacological properties and clinical efficacy in the management of advanced breast cancer

1 reference

12 December 2020

Side effects of ranitidine

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of irbesartan in patients with hepatic cirrhosis

1 reference

12 December 2020

Tiagabine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the management of epilepsy

1 reference

12 December 2020

Grepafloxacin pharmacokinetics in individuals with hepatic dysfunction

1 reference

12 December 2020

Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration

1 reference

12 December 2020

Clinical importance of non-genetic and genetic cytochrome P450 function tests in liver disease

1 reference

12 December 2020

Kinetics and dynamics of enalapril in patients with liver cirrhosis

1 reference

12 December 2020

First-pass metabolism of midazolam by the human intestine.

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12 December 2020

Drug metabolism in liver disease

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12 December 2020

Clinical pharmacokinetics of lansoprazole.

1 reference

12 December 2020

Hepatic lidocaine metabolism and liver histology in patients with chronic hepatitis and cirrhosis

1 reference

12 December 2020

Absolute bioavailability and pharmacokinetics of valsartan, an angiotensin II receptor antagonist, in man

1 reference

12 December 2020

Pharmacokinetics--a relevant factor for the choice of a drug?

1 reference

12 December 2020

Paroxetine. An update of its pharmacology and therapeutic use in depression and a review of its use in other disorders

1 reference

12 December 2020

Pharmacokinetics of ornidazole in patients with severe liver cirrhosis

1 reference

12 December 2020

10.2165/00003088-199937050-00004

Identifiers

DOI

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PubMed ID

10589374

Dimensions Publication ID

29 July 2017

0 references

1 reference

PubMed ID

10589374