(Q44364247)

2 December 2017

Metabotropic P2Y1 receptor signalling mediates astrocytic hyperactivity in vivo in an Alzheimer's disease mouse model (English)

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2 December 2017

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2

Martina Füchtemeier

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2 December 2017

Andrea Delekate

1

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2 December 2017

Toni Schumacher

3

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2 December 2017

Cordula Ulbrich

4

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2 December 2017

Marco Foddis

5

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2 December 2017

Gabor C Petzold

6

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2 December 2017

language of work or name

English

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publication date

19 November 2014

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2 December 2017

Nature Communications

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2 December 2017

5

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2 December 2017

5422

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https://scigraph.springernature.com/pub.10.1038/ncomms6422

2 December 2017

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cites work

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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https://api.crossref.org/works/10.1038%2FNCOMMS6422

Neurovascular regulation in the normal brain and in Alzheimer's disease

21 January 2018

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Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

21 January 2018

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Astrocytes, from brain glue to communication elements: the revolution continues

21 January 2018

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Role of astrocytes in neurovascular coupling.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6422

Molecular dissection of reactive astrogliosis and glial scar formation

21 January 2018

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Astroglia in dementia and Alzheimer's disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6422

Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS6422

Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Calcium dynamics of cortical astrocytic networks in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Large-scale calcium waves traveling through astrocytic networks in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Bulk loading of calcium indicator dyes to study astrocyte physiology: key limitations and improvements using morphological maps

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Sulforhodamine 101 induces long-term potentiation of intrinsic excitability and synaptic efficacy in hippocampal CA1 pyramidal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Astrocyte-mediated control of cerebral blood flow

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Astroglial networks: a step further in neuroglial and gliovascular interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

An astrocytic basis of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Imaging cellular network dynamics in three dimensions using fast 3D laser scanning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Connexin 43 hemichannels are permeable to ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Pathophysiology of astroglial purinergic signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Molecular physiology of P2X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Purinoceptors on neuroglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

GABA uptake-dependent Ca(2+) signaling in developing olfactory bulb astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Conditions and constraints for astrocyte calcium signaling in the hippocampal mossy fiber pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Selective loss of P2Y2 nucleotide receptor immunoreactivity is associated with Alzheimer's disease neuropathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Immunohistochemical localization of the P2Y1 purinergic receptor in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Analysis of the influence of nucleotidases on the apparent activity of exogenous ATP and ADP at P2Y1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Competitive and selective antagonism of P2Y1 receptors by N6-methyl 2'-deoxyadenosine 3',5'-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Neuroglia in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Amyloid deposition is associated with impaired default network function in older persons without dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Photochemically initiated intracellular astrocytic calcium waves in living mice using two-photon uncaging of IP(3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Impairment of in vivo calcium signaling in amyloid plaque-associated microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Purinergic signalling: from normal behaviour to pathological brain function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Astrocytic purinergic signaling coordinates synaptic networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

In vivo hippocampal (31)P NMR metabolites in Alzheimer's disease and ageing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Amyloid-β and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Aβ leads to Ca²⁺ signaling alterations and transcriptional changes in glial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Development of a method for the purification and culture of rodent astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Glutamate-dependent neuroglial calcium signaling differs between young and adult brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Beta-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Reactive oxygen species mediate the potentiating effects of ATP on GABAergic synaptic transmission in the immature hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Antagonism of purinergic signalling improves recovery from traumatic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Neurovascular function in Alzheimer's disease patients and experimental models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

A method to evaluate the diffusion rate of drugs from a microdialysis probe through brain tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Radially expanding transglial calcium waves in the intact cerebellum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

ATP mediates rapid microglial response to local brain injury in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Purinergic control of vascular tone in the retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

7 January 2021

Mapping of hippocampal pH and neurochemicals from in vivo multi-voxel 31P study in healthy normal young male/female, mild cognitive impairment, and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

7 January 2021

Hippocampal astrocytes in situ exhibit calcium oscillations that occur independent of neuronal activity

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

7 January 2021

Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS6422

7 January 2021

Identifiers

DOI

10.1038/NCOMMS6422

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2 December 2017

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1 reference