(Q44367477)

English

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile

scientific article published on 25 January 2003

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scholarly article

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Europe PubMed Central

PubMed publication ID

2 December 2017

Inhibition of skeletal muscle sodium currents by mexiletine analogues: specific hydrophobic interactions rather than lipophilia per se account for drug therapeutic profile (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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based on heuristic

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Annamaria De Luca

1

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Europe PubMed Central

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2 December 2017

Carlo Franchini

5

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Europe PubMed Central

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2 December 2017

Giovanni Lentini

6

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2 December 2017

8

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2 December 2017

Michela De Bellis

object named as

Michela De Bellis

3

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Diana Conte Camerino

10

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Diana Conte-Camerino

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Europe PubMed Central

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2 December 2017

Vincenzo Tortorella

9

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Vincenzo Tortorella

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

2

object named as

Sophie Talon

1 reference

Europe PubMed Central

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2 December 2017

Jean-François Desaphy

4

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Jean-François Desaphy

1 reference

Europe PubMed Central

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2 December 2017

Alessia Catalano

7

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Alessia Catalano

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2 December 2017

publication date

25 January 2003

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2 December 2017

Naunyn-Schmiedeberg's Archives of Pharmacology

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2 December 2017

367

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Europe PubMed Central

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2 December 2017

3

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2 December 2017

318-327

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2 December 2017

Molecular determinants of mexiletine structure for potent and use-dependent block of skeletal muscle sodium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipophilicity and membrane interactions of cationic-amphiphilic compounds: syntheses and structure-property relationships

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac-specific external paths for lidocaine, defined by isoform-specific residues, accelerate recovery from use-dependent block

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of new 2,6-prolylxylidide analogues of tocainide as stereoselective blockers of voltage-gated Na(+) channels with increased potency and improved use-dependent activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Na(+) current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homologation of mexiletine alkyl chain and stereoselective blockade of skeletal muscle sodium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved vaseline gap voltage clamp for skeletal muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Point mutations at N434 in D1-S6 of mu1 Na(+) channels modulate binding affinity and stereoselectivity of local anesthetic enantiomers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium channel blockers: the size/solubility hypothesis revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human muscle voltage-gated ion channels and hereditary disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminoalkyl structural requirements for interaction of lidocaine with the class I antiarrhythmic drug receptor on rat cardiac myocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between structure and sodium channel blockade by lidocaine and its amino-alkyl derivatives.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Residues in Na(+) channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of the antimyotonic activity of mexiletine and some new analogs on sodium currents of single muscle fibers and on the abnormal excitability of the myotonic ADR mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants of state-dependent block of Na+ channels by local anesthetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assessing the distribution of parameters in models of ligand-receptor interaction: to log or not to log.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of myotonia with antiarrhythmic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased rigidity of the chiral centre of tocainide favours stereoselectivity and use-dependent block of skeletal muscle Na(+) channels enhancing the antimyotonic activity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereoselective effects of mexiletine enantiomers on sodium currents and excitability characteristics of adult skeletal muscle fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and kinetic determinants of local anaesthetic action on sodium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of Mexiletine Stereoisomers and Related Compounds via S(N)Ar Nucleophilic Substitution of a Cr(CO)(3)-Complexed Aromatic Fluoride

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of frog skeletal muscle sodium channels by newly synthesized chiral derivatives of mexiletine and tocainide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disparate role of Na(+) channel D2-S6 residues in batrachotoxin and local anesthetic action

1 reference

https://pubmed.ncbi.nlm.nih.gov/12644906

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-002-0669-0

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

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