(Q44372189)

English

Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses

scientific article published on 21 March 2003

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

author name string

Jerry L Jeffrey

1

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Joy Y Feng

2

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

C C Richard Qi

3

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Karen S Anderson

4

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Phillip A Furman

5

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

language of work or name

0 references

publication date

21 March 2003

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

278

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

21

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

18971-18979

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (-)-beta-D-dioxolane-guanosine and suppress resistance to 3'-azido-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase: evidence of discrimination between DNA and RNA substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Mutational analysis of Lys65 of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Molecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Mechanism of resistance of human immunodeficiency virus type 1 to 2',3'-dideoxyinosine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Perspectives on inducing efficient immune control of HIV-1 replication--a new goal for HIV therapeutics?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Role of glutamine-151 of human immunodeficiency virus type-1 reverse transcriptase in RNA-directed DNA synthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in substrate selection as assessed by site-directed mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Functional analysis of amino acid residues constituting the dNTP binding pocket of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Single-step kinetics of HIV-1 reverse transcriptase mutants responsible for virus resistance to nucleoside inhibitors zidovudine and 3-TC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Mechanistic studies examining the efficiency and fidelity of DNA synthesis by the 3TC-resistant mutant (184V) of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Mechanism-based suppression of dideoxynucleotide resistance by K65R human immunodeficiency virus reverse transcriptase using an alpha-boranophosphate nucleoside analogue.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Resistance to non-nucleoside inhibitors of HIV-1 reverse transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Comparison of genotyping and phenotyping methods for determining susceptibility of HIV-1 to antiretroviral drugs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Inhibition of viral polymerases by chain-terminating substrates: a kinetic analysis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M210113200

21 January 2018

Identifiers

10.1074/JBC.M210113200

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

2 December 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q44372189&oldid=2020526367"