(Q44442532)

3 December 2017

title

Contraceptive activity of a spermicidal aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07) in rabbits (English)

1 reference

3 December 2017

2

Fatih M Uckun

1 reference

3 December 2017

Osmond J. D'Cruz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12749422

2 January 2024

language of work or name

English

0 references

publication date

1 April 2003

1 reference

full work available at URL

3 December 2017

http://www.fertstert.org/article/S0015028202048458/pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12749422

https://api.elsevier.com/content/article/PII:S0015028202048458?httpAccept=text/xml

2 January 2024

1 reference

https://api.crossref.org/works/10.1016/S0015-0282(02)04845-8

https://api.elsevier.com/content/article/PII:S0015028202048458?httpAccept=text/plain

2 January 2024

1 reference

https://api.crossref.org/works/10.1016/S0015-0282(02)04845-8

2 January 2024

published in

Fertility and Sterility

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3 December 2017

volume

79

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3 December 2017

issue

4

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3 December 2017

page(s)

864-872

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Global burden of the HIV pandemic

3 December 2017

cites work

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Prophylactic contraceptives for HIV/AIDS

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Aryl phosphate derivatives of bromo-methoxy-azidothymidine are dual-function spermicides with potent anti-human immunodeficiency virus

7 January 2021

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Synthesis of dual function (5R,6R)- and (5S,6S)-5-bromo-6-methoxy-5,6-dihydro-AZT-5'-(para-bromophenyl methoxyalaninyl phosphate) as novel spermicidal and anti-HIV agents

7 January 2021

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WHI-05, a novel bromo-methoxy substituted phenyl phosphate derivative of zidovudine, is a dual-action spermicide with potent anti-HIV activity

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

Synthesis, characterization and preclinical formulation of a dual-action phenyl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07) with potent anti-HIV and spermicidal activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

Structural requirements for potent human spermicidal activity of dual-function aryl phosphate derivative of bromo-methoxy zidovudine (compound WHI-07)

7 January 2021

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Importance of the alanine methyl ester side chain for the biological activity profile of dual-function phenyl phosphate derivatives of bromo-methoxy-zidovudine

7 January 2021

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Effect of commercial contraceptive jellies placed into the rabbit vagina before mating

7 January 2021

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Vaginal delivery of new formulations of nonoxynol-9 coprecipitated with polyvinylpyrrolidone in rabbits. Comparisons between two formulation delivery systems

7 January 2021

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Gel-microemulsions as vaginal spermicides and intravaginal drug delivery vehicles

7 January 2021

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Effect of pretreatment of semen with pokeweed antiviral protein on pregnancy outcome in the rabbit model

7 January 2021

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Contraceptive efficacy and safety studies of a novel microemulsion-based lipophilic vaginal spermicide

7 January 2021

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GM-144, a novel lipophilic vaginal contraceptive gel-microemulsion

7 January 2021

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EFFECT OF DILUTION RATE AND OF THE NUMBER OF SPERMATOZOA INSEMINATED ON THE FERTILITY OF RABBITS OVULATED WITH CHORIONIC GONADOTROPHIN

7 January 2021

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Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby

7 January 2021

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Contraceptive testing of vaginal agents in rabbits

7 January 2021

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Contraceptive effect of sperm-agglutinating monoclonal antibodies in rabbits

7 January 2021

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Relative antifertility activity of three vaginal contraceptive products in the rabbit: Relationship to in vitro data

7 January 2021

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Pre-clinical safety evaluation of novel nucleoside analogue-based dual-function microbicides (WHI-05 and WHI-07).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

Lack of adverse effects on fertility of female CD-1 mice exposed to repetitive intravaginal gel-microemulsion formulation of a dual-function anti-HIV agent: aryl phosphate derivative of bromo-methoxy-zidovudine (compound WHI-07).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

Evaluation of subchronic (13-week) and reproductive toxicity potential of intravaginal gel-microemulsion formulation of a dual-function phenyl phosphate derivative of bromo-methoxy zidovudine (compound whi-07) in B(6)C(3)F(1) mice.

7 January 2021

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Short-Term (13-week) toxicity study of 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent, in B6C3F1 mice

7 January 2021

1 reference

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Two-year toxicity and carcinogenicity studies in B(6)C(3)F(1) mice with 5-bromo-6-methoxy-5,6-dihydro-3'-azidothymidine-5'-(p-bromophenyl) methoxyalaninyl phosphate (WHI-07), a novel anti-HIV and contraceptive agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

Thymidine kinase-independent intracellular delivery of bioactive nucleotides by aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07) in normal human female genital tract epithelial cells and sperm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

Sperm as infection-potentiating cofactors in HIV transmission

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0015-0282%2802%2904845-8

Women & HIV. Adolescent sexuality, gender, and the HIV epidemic

7 January 2021

series ordinal

11

1 reference

https://api.crossref.org/works/10.1016/S0015-0282(02)04845-8

2 January 2024

Identifiers

1 reference

3 December 2017

1 reference