(Q44503698)

English

No influence of mild-to-moderate hepatic impairment on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor

scientific article published in January 2003

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

No influence of mild-to-moderate hepatic impairment on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor (English)

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

pharmacokinetics

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Karin Wåhlander

1

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Maria Eriksson-Lepkowska

2

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Lars Frison

3

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Gunnar Fager

4

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Ulf G Eriksson

5

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

publication date

1 January 2003

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

42

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

755-764

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

https://scigraph.springernature.com/pub.10.2165/00003088-200342080-00004

0 references

A dose-ranging study of the oral direct thrombin inhibitor, ximelagatran, and its subcutaneous form, melagatran, compared with dalteparin in the prophylaxis of thromboembolism after hip or knee replacement: METHRO I. MElagatran for THRombin inhibiti

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of ximelagatran, an oral direct thrombin inhibitor, its active metabolite melagatran, and the intermediate metabolites, in biological samples by liquid chromatography-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of melagatran on prothrombin time assays depends on the sensitivity of the thromboplastin and the final dilution of the plasma sample.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of melagatran, a novel synthetic LMW thrombin inhibitor, in patients with acute DVT

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antithrombotic effects and bleeding time of thrombin inhibitors and warfarin in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 30-minute aminopyrine breath test: optimization of sampling times after intravenous administration of 14C-aminopyrine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

No Influence of Ethnic Origin on the Pharmacokinetics and Pharmacodynamics of Melagatran Following Oral Administration of Ximelagatran, a Novel Oral Direct Thrombin Inhibitor, to Healthy Male Volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability, and safety study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of hepatic insufficiency on pharmacokinetics and drug dosing

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, controlled, dose-guiding study of the oral direct thrombin inhibitor ximelagatran compared with standard therapy for the treatment of acute deep vein thrombosis: THRIVE I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving subcutaneous melagatran and oral ximelagatran: a population model analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption, distribution, metabolism, and excretion of ximelagatran, an oral direct thrombin inhibitor, in rats, dogs, and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug administration in chronic liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics, pharmacodynamics and clinical effects of the oral direct thrombin inhibitor ximelagatran in acute treatment of patients with pulmonary embolism and deep vein thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of creatinine clearance from serum creatinine

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transection of the oesophagus for bleeding oesophageal varices

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic disease and drug pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug metabolism in liver disease: implications for therapeutic drug monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics in patients with liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interpretation of the international normalised ratio in patients with liver disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The direct thrombin inhibitor melagatran and its oral prodrug H 376/95: intestinal absorption properties, biochemical and pharmacodynamic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of thrombin generation by the oral direct thrombin inhibitor ximelagatran in shed blood from healthy male subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The importance of enzyme inhibition kinetics for the effect of thrombin inhibitors in a rat model of arterial thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ximelagatran and melagatran compared with dalteparin for prevention of venous thromboembolism after total hip or knee replacement: the METHRO II randomised trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetic and pharmacodynamic considerations in patients with liver disease. An update

1 reference

https://pubmed.ncbi.nlm.nih.gov/12846596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2165/00003088-200342080-00004

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 December 2017

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