(Q44541814)

4 December 2017

title

A dual mechanism of action of the anticancer agent F 11782 on human topoisomerase II alpha (English)

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4 December 2017

3

Karin C Nitiss

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4 December 2017

5

John L Nitiss

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4 December 2017

Lars H Jensen

1

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4 December 2017

Axelle Renodon-Cornière

2

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4 December 2017

Bridget T Hill

4

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4 December 2017

Peter B Jensen

6

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4 December 2017

Maxwell Sehested

7

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4 December 2017

language of work or name

English

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publication date

1 August 2003

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4 December 2017

published in

Biochemical Pharmacology

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4 December 2017

volume

66

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4 December 2017

issue

4

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4 December 2017

page(s)

623-631

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Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine

4 December 2017

cites work

1 reference

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Investigating the biological functions of DNA topoisomerases in eukaryotic cells

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Cellular roles of dna topoisomerases: a molecular perspective

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DNA topoisomerases: essential enzymes and lethal targets

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Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice

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Catalytic inhibitors of DNA topoisomerase II

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Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage

7 January 2021

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Maleimide is a potent inhibitor of topoisomerase II in vitro and in vivo: a new mode of catalytic inhibition.

7 January 2021

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Stabilization of type I topoisomerase-DNA covalent complexes by actinomycin D

7 January 2021

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F 11782, a novel epipodophylloid non-intercalating dual catalytic inhibitor of topoisomerases I and II with an original mechanism of action

7 January 2021

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F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103.

7 January 2021

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Characterization of DNA-strand breakage induced in V79 cells by F 11782, a catalytic inhibitor of topoisomerases

7 January 2021

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Inhibition of nucleotide excision repair and sensitisation of cells to DNA cross-linking anticancer drugs by F 11782, a novel fluorinated epipodophylloid

7 January 2021

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Synergistic effects of F 11782, a novel dual inhibitor of topoisomerases I and II, in combination with other anticancer agents

7 January 2021

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Human small cell lung cancer NYH cells resistant to the bisdioxopiperazine ICRF-187 exhibit a functional dominant Tyr165Ser mutation in the Walker A ATP binding site of topoisomerase II alpha.

7 January 2021

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Differential cytotoxicity of 19 anticancer agents in wild type and etoposide resistant small cell lung cancer cell lines

7 January 2021

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A quantitative decatenation assay for type II topoisomerases

7 January 2021

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Interaction of human DNA topoisomerase II alpha with DNA: quantification by surface plasmon resonance

7 January 2021

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Steady-state and rapid kinetic analysis of topoisomerase II trapped as the closed-clamp intermediate by ICRF-193

7 January 2021

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A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines

7 January 2021

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Kinetic and thermodynamic analysis of mutant type II DNA topoisomerases that cannot covalently cleave DNA.

7 January 2021

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Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp

7 January 2021

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The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases

7 January 2021

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Incomplete reversion of double stranded DNA cleavage mediated by Drosophila topoisomerase II: formation of single stranded DNA cleavage complex in the presence of an anti-tumor drug VM26

7 January 2021

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Characterization of the biological and biochemical activities of F 11782 and the bisdioxopiperazines, ICRF-187 and ICRF-193, two types of topoisomerase II catalytic inhibitors with distinctive mechanisms of action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900342-3

In vivo antitumor activity of F 11782, a non-intercalating dual catalytic inhibitor of topoisomerases I and II, against a panel of human tumor xenografts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-2952%2803%2900342-3

10.1016/S0006-2952(03)00342-3

7 January 2021

Identifiers

DOI

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4 December 2017

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