(Q44563409)

4 December 2017

title

The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation (English)

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4 December 2017

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4

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4 December 2017

6

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4 December 2017

7

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4 December 2017

I Murfuni

1

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4 December 2017

S Nicolai

series ordinal

2

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4 December 2017

S Baldari

series ordinal

3

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4 December 2017

M Bignami

series ordinal

5

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4 December 2017

language of work or name

English

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publication date

12 March 2012

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4 December 2017

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4 December 2017

volume

32

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4 December 2017

issue

5

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4 December 2017

page(s)

610-620

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https://scigraph.springernature.com/pub.10.1038/onc.2012.80

4 December 2017

exact match

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cites work

Genomic instability--an evolving hallmark of cancer

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https://api.crossref.org/works/10.1038%2FONC.2012.80

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

An oncogene-induced DNA damage model for cancer development

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

Nucleotide deficiency promotes genomic instability in early stages of cancer development

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

Maintaining genome stability at the replication fork

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

More forks on the road to replication stress recovery

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

Pathways of mammalian replication fork restart.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

The ATR barrier to replication-born DNA damage.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

ATR: an essential regulator of genome integrity

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

ATR/Mec1: coordinating fork stability and repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Chromosome breakage syndromes and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Protecting genomic integrity during DNA replication: correlation between Werner's and Bloom's syndrome gene products and the MRE11 complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Roles of Werner syndrome protein in protection of genome integrity

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

The Werner syndrome protein: linking the replication checkpoint response to genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

Mutation of hCDC4 leads to cell cycle deregulation of cyclin E in cancer.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

The retinoblastoma protein pathway in cell cycle control and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.80

DNA damage signalling guards against activated oncogenes and tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

c-Myc accelerates S-phase and requires WRN to avoid replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

The controlling role of ATM in homologous recombinational repair of DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Homologous recombination resolution defect in werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Werner's syndrome protein is required for correct recovery after replication arrest and DNA damage induced in S-phase of cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

The Bloom's syndrome helicase suppresses crossing over during homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Aberrant chromosome morphology in human cells defective for Holliday junction resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Mus81 is essential for sister chromatid recombination at broken replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Mus81-Eme1 and Rqh1 involvement in processing stalled and collapsed replication forks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Synthetic lethality of Drosophila in the absence of the MUS81 endonuclease and the DmBlm helicase is associated with elevated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Werner syndrome helicase activity is essential in maintaining fragile site stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

21 January 2018

Chromosome fragile sites

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

Reconstitution of cyclin D1-associated kinase activity drives terminally differentiated cells into the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.80

21 January 2018

Identifiers

DOI

10.1038/ONC.2012.80

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4 December 2017

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