(Q44588836)

English

Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf

scientific article published in September 2003

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scholarly article

1 reference

Europe PubMed Central

4 December 2017

Farnesyltransferase inhibitors are potent lung cancer chemopreventive agents in A/J mice with a dominant-negative p53 and/or heterozygous deletion of Ink4a/Arf (English)

1 reference

Europe PubMed Central

4 December 2017

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author name string

Zhongqiu Zhang

1

1 reference

Europe PubMed Central

4 December 2017

Yian Wang

2

1 reference

Europe PubMed Central

4 December 2017

Laura E Lantry

3

1 reference

Europe PubMed Central

4 December 2017

Elizabeth Kastens

4

1 reference

Europe PubMed Central

4 December 2017

Gongjie Liu

5

1 reference

Europe PubMed Central

4 December 2017

Andrew D Hamilton

6

1 reference

Europe PubMed Central

4 December 2017

Said M Sebti

7

1 reference

Europe PubMed Central

4 December 2017

Ronald A Lubet

8

1 reference

Europe PubMed Central

4 December 2017

Ming You

9

1 reference

Europe PubMed Central

4 December 2017

language of work or name

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publication date

1 September 2003

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Europe PubMed Central

4 December 2017

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Europe PubMed Central

4 December 2017

22

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4 December 2017

6257-6265

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4 December 2017

40

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4 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.onc.1206630

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Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

21 January 2018

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

21 January 2018

p21ras is modified by a farnesyl isoprenoid

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

21 January 2018

Use of p53 transgenic mice in the development of cancer models for multiple purposes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

21 January 2018

Inactivation of both Rb and p53 pathways in mouse lung epithelial cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

21 January 2018

Farnesyltransferase inhibitors: antineoplastic properties, mechanisms of action, and clinical prospects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

21 January 2018

Activation of the Ki-ras protooncogene in spontaneously occurring and chemically induced lung tumors of the strain A mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

21 January 2018

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

inferred from DOI database lookup

The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

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Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

inferred from DOI database lookup

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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The Ras signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

inferred from DOI database lookup

Cancer statistics, 1998.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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Chemopreventive efficacy of promising farnesyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

inferred from DOI database lookup

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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Theoretical and empirical issues for marker-assisted breeding of congenic mouse strains

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

inferred from DOI database lookup

5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibitors of Ras farnesyltransferases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206630

7 January 2021

based on heuristic

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Identifiers

10.1038/SJ.ONC.1206630

1 reference

Europe PubMed Central

4 December 2017

1 reference

Europe PubMed Central

4 December 2017

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